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Gene Review:

LOC395824 - vitamin D3 hydroxylase associated protein

Gallus gallus

Ettinger, R.A. et al., Ettinger, R.A. et al.

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High impact information on LOC395824

VDHAP is a novel chick kidney-specific inner membrane protein of mitochondria, which associates with a fraction of the 1,25-dihydroxyvitamin D3-24R-hydroxylase and 25-hydroxyvitamin D3-1 alpha-hydroxylase [1].
The deduced amino acid sequence agreed with an NH2-terminal amino acid sequence from the isolated VDHAP [1].
These antibodies were used to screen a chick kidney lambda gt11 cDNA library resulting in the isolation of a full-length cDNA encoding a protein that is not the 1,25-dihydroxyvitamin D3-24R-hydroxylase but another protein we term the vitamin D3 hydroxylase-associated protein (VDHAP) [1].
The vitamin D3 hydroxylase-associated protein is a propionamide-metabolizing amidase enzyme [2].
A protein consensus sequence dictionary, MOTIFS, identified an amidase consensus sequence in VDHAP [2].

References

cDNA cloning and characterization of a vitamin D3 hydroxylase-associated protein. Ettinger, R.A., Ismail, R., DeLuca, H.F. J. Biol. Chem. (1994) [Pubmed]
The vitamin D3 hydroxylase-associated protein is a propionamide-metabolizing amidase enzyme. Ettinger, R.A., DeLuca, H.F. Arch. Biochem. Biophys. (1995) [Pubmed]

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