Gene Review:
KRT19 - keratin 19
Gallus gallus
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High impact information on KRT19
- Hence, FIB, ALB, and CK19 expression can be used to trace hepatic induction, maturation, and bile duct differentiation, respectively [1].
- Cytokeratin 19 (CK19) was first detected at stage 37 in the ductal plate of the liver, and its expression continued in the intrahepatic bile ducts derived from the ductal plate [1].
- Furthermore, GK-19 was localized in the notochord, floor plate, anterior lobe of the pituitary gland and mesonephros [2].
- The result of in situ hybridization with the proventriculus (glandular stomach) of different developmental stages showed that GK-19 expression disappeared specifically in the glandular epithelium from day 6 to day 9 of incubation [2].
- These results suggest the possibility that GK-19 may have multiple roles in organogenesis during embryogenesis [2].
Anatomical context of KRT19
- To learn the role of keratin in digestive tract development, a cDNA of the chicken homolog of keratin-19 (GK-19) was cloned and its expression pattern was analyzed in the digestive tract of chicken embryos [2].
References
- Analysis of gene expression patterns in the developing chick liver. Yanai, M., Tatsumi, N., Endo, F., Yokouchi, Y. Dev. Dyn. (2005) [Pubmed]
- Chicken keratin-19: cloning of cDNA and analysis of expression in the chicken embryonic gut. Sato, K., Yasugi, S. Dev. Growth Differ. (1997) [Pubmed]
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