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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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MGP  -  matrix Gla protein

Gallus gallus

 
 
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High impact information on MGP

  • Virally driven MGP overexpression in cultured chondrocytes greatly decreased mineralization [1].
  • Matrix GLA protein (MGP), a gamma-carboxyglutamic acid (GLA)-rich, vitamin K-dependent and apatite-binding protein, is a regulator of hypertrophic cartilage mineralization during development [1].
  • Warfarin effects on mineralization were highly selective, were accompanied by no appreciable changes in MGP expression, alkaline phosphatase activity, or cell number, and were counteracted by vitamin K cotreatment [1].
  • To address these issues, we determined the effects of manipulations of MGP synthesis and expression in (a) immature and hypertrophic chondrocyte cultures and (b) the chick limb bud in vivo [1].
  • The two chondrocyte cultures displayed comparable levels of MGP gene expression [1].
 

Anatomical context of MGP

 

Analytical, diagnostic and therapeutic context of MGP

References

  1. Matrix GLA protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limb. Yagami, K., Suh, J.Y., Enomoto-Iwamoto, M., Koyama, E., Abrams, W.R., Shapiro, I.M., Pacifici, M., Iwamoto, M. J. Cell Biol. (1999) [Pubmed]
  2. Molecular cloning of avian matrix Gla protein. Wiedemann, M., Trueb, B., Belluoccio, D. Biochim. Biophys. Acta (1998) [Pubmed]
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