High impact information on IKZF1

• Importantly, the Ikaros mRNA is already expressed in early chicken embryos, from embryonic day 2 onwards, thus markedly before the traffic of the first precursor cells to the lymphoid primordia, thymus and the bursa of Fabricius [1].
• Avian Ikaros gene is expressed early in embryogenesis [1].
• To reveal the evolutionary aspects of regulatory molecules involved in early lymphocyte development, we studied the cDNA of the avian Ikaros homolog [1].
• The Ikaros family of transcription factors plays an essential role in hematopoiesis [2].

Analytical, diagnostic and therapeutic context of IKZF1

• In situ hybridization demonstrates that Ikaros transcripts are abundant at the periphery of the thymus lobes, in the presumptive site of early thymocyte differentiation [2].

References