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FGF1  -  fibroblast growth factor 1 (acidic)

Gallus gallus

Synonyms: ECGF, FGF-1
 
 
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Disease relevance of FGF1

  • Consistent with previous studies, blocking FGF receptor activation with a specific inhibitor to the FGFRs retards the movement of the front of ganglion cell differentiation, while application of exogenous FGF1 causes the precocious development of ganglion cells in peripheral retina [1].
  • The aFGF rescue effect could only be demonstrated for subconjunctival delivery; high intravitreal doses (> or = 300 ng per injection) induced retinal detachment and photoreceptor degeneration, while doses of aFGF close to the ED50 for bFGF (3 ng per injection) were completely ineffective [2].
 

High impact information on FGF1

  • Remarkably, beads soaked in FGF-1, FGF-2, or FGF-4 and placed in the presumptive flank of chick embryos induce formation of ectopic limb buds, which can develop into complete limbs [3].
  • The notion that the isolated mitogens represent chick aFGF is further supported by the findings that their affinity for heparin and their retention behavior in highly resolutive HPLC are indistinguishable from those of genuine aFGF [4].
  • Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factor [4].
  • In vivo treatment of developing chick embryos with acidic and basic fibroblast growth factors (aFGF and bFGF) failed to affect the differentiation and survival of several populations of developing neurons in the CNS and PNS [5].
  • In dorsal root ganglia, aFGF was found to be expressed after embryonic day 6 [6].
 

Biological context of FGF1

 

Anatomical context of FGF1

 

Associations of FGF1 with chemical compounds

  • However, polyanethole sulfonate, the carrageenans, polyvinyl sulphate, fucoidin, and pentosan sulphate exerted a mitogenic action on the 3T3 cells that was independent of, and in addition to, the ability of these GAGs to potentiate the action of aFGF [13].
  • Our data show that FGF-1 and FGF-2 are mitogenic for chicken granulosa and theca cells, and indicate that the actions of FGF-2 may be mediated via both tyrosine-kinase-type and glycosaminoglycan-type receptors on the surface of these cells [14].
 

Other interactions of FGF1

  • We have examined the consequences of selectively and independently inhibiting FGF1 or FGF2 expression using antisense oligonucleotides in embryonic chick retinal cells, differentiating in vitro [7].
  • The involvement of the AKT pathway was demonstrated by up-regulation of AKT1 mRNA expression in sp-FGF-1 compared to vector alone control transfected CAMs as demonstrated by real-time RT-PCR [10].
 

Analytical, diagnostic and therapeutic context of FGF1

  • Heparin-sepharose affinity chromatography suggests that the biological activities of CAF probably correspond to the presence of acidic and basic fibroblast growth factor (aFGF and bFGF) [15].
  • The concentration of aFGF was measured using an enzyme immuno assay and showed an accumulation of this protein only in bFGF-treated cultures, suggesting that bFGF positively modulates aFGF synthesis in neural retina cell cultures [16].
  • By using quantitative RT-PCR, FGF-1 mRNA expression was found to be significantly decreased in ALD muscles stretched for 2 or 11 days [17].
  • Both activity and mRNA expression levels of the Ets-1 molecule were increased in response to FGF-1 overexpression in CAMs, as documented by electrophoretic mobility shift assay (gel shift) and reverse transcription real-time PCR techniques, respectively [18].

References

  1. The development of the pattern of retinal ganglion cells in the chick retina: mechanisms that control differentiation. McCabe, K.L., Gunther, E.C., Reh, T.A. Development (1999) [Pubmed]
  2. Basic fibroblast growth factor (bFGF) and transforming growth factor beta (TGF-beta) act as stop and go signals to modulate postnatal ocular growth in the chick. Rohrer, B., Stell, W.K. Exp. Eye Res. (1994) [Pubmed]
  3. Fibroblast growth factors induce additional limb development from the flank of chick embryos. Cohn, M.J., Izpisúa-Belmonte, J.C., Abud, H., Heath, J.K., Tickle, C. Cell (1995) [Pubmed]
  4. Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factor. Risau, W., Gautschi-Sova, P., Böhlen, P. EMBO J. (1988) [Pubmed]
  5. The lack of effect of basic and acidic fibroblast growth factors on the naturally occurring death of neurons in the chick embryo. Oppenheim, R.W., Prevette, D., Fuller, F. J. Neurosci. (1992) [Pubmed]
  6. Differentiating and mature neurons express the acidic fibroblast growth factor gene during chick neural development. Schnürch, H., Risau, W. Development (1991) [Pubmed]
  7. Suppression of fibroblast growth factors 1 and 2 by antisense oligonucleotides in embryonic chick retinal cells in vitro inhibits neuronal differentiation and survival. Désiré, L., Courtois, Y., Jeanny, J.C. Exp. Cell Res. (1998) [Pubmed]
  8. Phosphorylation-dependent regulation of cardiac Na+/Ca2+ exchanger via protein kinase C. Iwamoto, T., Pan, Y., Wakabayashi, S., Imagawa, T., Yamanaka, H.I., Shigekawa, M. J. Biol. Chem. (1996) [Pubmed]
  9. Association of fibroblast growth factor receptor-1 with c-Src correlates with association between c-Src and cortactin. Zhan, X., Plourde, C., Hu, X., Friesel, R., Maciag, T. J. Biol. Chem. (1994) [Pubmed]
  10. Role of AKT/PKB signaling in fibroblast growth factor-1 (FGF-1)-induced angiogenesis in the chicken chorioallantoic membrane (CAM). Forough, R., Weylie, B., Patel, C., Ambrus, S., Singh, U.S., Zhu, J. J. Cell. Biochem. (2005) [Pubmed]
  11. FGF7 and FGF10 directly induce the apical ectodermal ridge in chick embryos. Yonei-Tamura, S., Endo, T., Yajima, H., Ohuchi, H., Ide, H., Tamura, K. Dev. Biol. (1999) [Pubmed]
  12. The expression of messenger RNAs coding for growth factors, their receptors, and eph-class receptor tyrosine kinases in normal and ototoxically damaged chick cochleae. Pickles, J.O., van Heumen, W.R. Dev. Neurosci. (1997) [Pubmed]
  13. Investigation of the ability of several naturally occurring and synthetic polyanions to bind to and potentiate the biological activity of acidic fibroblast growth factor. Belford, D.A., Hendry, I.A., Parish, C.R. J. Cell. Physiol. (1993) [Pubmed]
  14. Mitogenic effects of fibroblast growth factors on chicken granulosa and theca cells in vitro. Roberts, R.D., Ellis, R.C. Biol. Reprod. (1999) [Pubmed]
  15. Mitogenic activity of chicken chorioallantoic fluid is temporally correlated to vascular growth in the chorioallantoic membrane and related to fibroblast growth factors. Flamme, I., Schulze-Osthoff, K., Jacob, H.J. Development (1991) [Pubmed]
  16. Effects of exogenous FGFs on growth, differentiation, and survival of chick neural retina cells. Tcheng, M., Oliver, L., Courtois, Y., Jeanny, J.C. Exp. Cell Res. (1994) [Pubmed]
  17. Expression of fibroblast growth factor family during postnatal skeletal muscle hypertrophy. Mitchell, P., Steenstrup, T., Hannon, K. J. Appl. Physiol. (1999) [Pubmed]
  18. Transcription factor Ets-1 regulates fibroblast growth factor-1-mediated angiogenesis in vivo: role of Ets-1 in the regulation of the PI3K/AKT/MMP-1 pathway. Forough, R., Weylie, B., Collins, C., Parker, J.L., Zhu, J., Barhoumi, R., Watson, D.K. J. Vasc. Res. (2006) [Pubmed]
 
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