High impact information on CRYBB3

• The relative levels of beta A2-crystallin remained stable from five days of embryogenesis until adulthood, while the relative amounts of beta B3-crystallin increased until hatching and were appreciably lower in the adult lens [1].
• In vitro and in vivo phosphorylation of chicken beta B3-crystallin [2].

Analytical, diagnostic and therapeutic context of CRYBB3

• By Northern blot hybridization analysis, both beta A2- and beta B3-crystallin were shown to be lens-specific in the chicken embryo [1].
• The protein is present in the beta-crystallin fraction and after purification and partial sequence determination, by way of peptide mapping and subsequent amino acid analyses and Edman degradation, this 28 kDa protein was identified as the beta B3-crystallin subunit, based on its homology with the bovine and rat orthologue [2].

References