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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PRRX2  -  paired related homeobox 2

Gallus gallus

Synonyms: PMX2, PRX-2, PRX2, S8
 
 
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High impact information on PRRX2

  • The presumptive promoter and 5'-flanking regions contain an E2 box and consensus binding sites for SP1, for the S8 homeodomain protein, and for two zinc finger clusters within the myeloid progenitor transcription factor, MZF1 [1].
  • PRX1 (MHox) and PRX2 (S8) were previously shown to be expressed throughout embryogenesis in complex, mostly mesenchyme-specific patterns [2].
  • PRX2 patterns deviated at later stages from those of PRX1 and showed specific and high transcript levels in the ductus arteriosus from embryonic day 6 onward [2].

References

  1. Organization of the chick CDC37 gene. Huang, L., Grammatikakis, N., Toole, B.P. J. Biol. Chem. (1998) [Pubmed]
  2. Patterns of paired-related homeobox genes PRX1 and PRX2 suggest involvement in matrix modulation in the developing chick vascular system. Bergwerff, M., Gittenberger-de Groot, A.C., DeRuiter, M.C., van Iperen, L., Meijlink, F., Poelmann, R.E. Dev. Dyn. (1998) [Pubmed]
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