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EEF2  -  eukaryotic translation elongation factor 2

Gallus gallus

 
 
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Disease relevance of EEF2

 

High impact information on EEF2

  • Functional characterization of the promoter region of the chicken elongation factor-2 gene [2].
  • The sequence between nucleotides -700 and -550 was determined to be a regulatory region for the chicken EF-2 basal promoter activity [2].
  • 8-bromo-cAMP increased chicken EF-2 promoter activity (-700/+102) in Rat 1 HIR fibroblast cells more than insulin and phorbol ester treatment [2].
  • Embryonic chicken muscle cells (CELM) contain the calmodulin-dependent protein kinase that specifically phosphorylates eukaryotic elongation factor 2 [3].
  • The 100-kDa protein, whose phosphorylation precedes the fusion of chick embryonic myoblasts, is the eukaryotic elongation factor-2 [4].
 

Biological context of EEF2

 

Anatomical context of EEF2

  • Our results suggest the presence of other EF-2 kinase in chick embryo cell than the previously reported Ca2+/calmodulin-dependent protein kinase III [5].
  • These results indicate that the 100-kDa protein in chick embryonic myoblasts is identical to the eukaryotic elongation factor-2 [4].
  • The amount of EF2 bound to ribosomes was identical in normal and dystrophic muscles during all stages of development [1].
  • Purification and characterization of homogeneous protein synthesis elongation factor 2 from hen oviduct [6].
  • Using differential display, four genes, B-cadherin, EF2, HT7 and Ex-FABP were cloned from chondrocytes stimulated to differentiate to the hypertrophic stage in vitro, and their differential expression confirmed in vivo [7].
 

Associations of EEF2 with chemical compounds

 

Analytical, diagnostic and therapeutic context of EEF2

  • Peptide mapping patterns of partial proteolytic fragments of EF2 from normal and dystrophic chicken breast muscles were similar [1].

References

  1. Increase in the amount of elongation factor 2 in chicken muscular dystrophy. Yoshikawa, A., Takano-Ohmuro, H., Masaki, T. Muscle Nerve (1984) [Pubmed]
  2. Functional characterization of the promoter region of the chicken elongation factor-2 gene. Lim, E.J., Kim, C.W. Gene (2007) [Pubmed]
  3. Kinetics of calcium and calmodulin-dependent protein kinase III from embryonic chicken leg muscle cells. Riis, B., Nygård, O. FEBS Lett. (1997) [Pubmed]
  4. The 100-kDa protein, whose phosphorylation precedes the fusion of chick embryonic myoblasts, is the eukaryotic elongation factor-2. Jeon, Y.J., Kim, H.S., Kim, H.S., Kang, M.S., Chung, C.H., Ha, D.B. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  5. Elongation factor-2 in chick embryo is phosphorylated on tyrosine as well as serine and threonine. Kim, Y.W., Kim, C.W., Kang, K.R., Byun, S.M., Kang, Y.S. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  6. Purification and characterization of homogeneous protein synthesis elongation factor 2 from hen oviduct. Comstock, J.P., Van, N.T. Biochim. Biophys. Acta (1977) [Pubmed]
  7. Expression patterns of chondrocyte genes cloned by differential display in tibial dyschondroplasia. Jefferies, D., Houston, B., Lester, D., Whitehead, C.C., Thorp, B.H., Botman, M., Farquharson, C. Biochim. Biophys. Acta (2000) [Pubmed]
  8. Phosphorylation of eukaryotic elongation factor 2 can be regulated by phosphoinositide 3-kinase in the early stages of myoblast differentiation. Woo, J.H., Kim, H.S. Mol. Cells (2006) [Pubmed]
 
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