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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

C3  -  complement component 3

Gallus gallus

 
 
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High impact information on C3

  • The convertase cleavage site, predicted to be Arg-Ser, was confirmed by sequencing the zymosan-bound C3 fragments generated upon complement activation [1].
  • NH2-terminal sequencing of the purified C3 chains showed that 1) pro-C3 is indeed cleaved at the RKRR linker sequence to generate the mature two-chain molecule, and 2) the beta-chain of chicken C3 is blocked [1].
  • The deduced amino acid sequence shows 54, 54, 54, 53, 52, 57, and 55% amino acid identities to human, mouse, rat, guinea pig, rabbit, cobra, and Xenopus C3, respectively, and an identity of 44, 31, and 33% to trout, hagfish, and lamprey C3, respectively [1].
  • Receptor-mediated transport and deposition of complement component C3 into developing chicken oocytes [2].
 

Analytical, diagnostic and therapeutic context of C3

  • The complete cDNA sequence of chicken C3 was obtained by screening a chicken liver lambda gt10 library with the C3 PCR product and probes from the 5' end of the partial-length C3 clones [1].

References

  1. Isolation, primary structure, and evolution of the third component of chicken complement and evidence for a new member of the alpha 2-macroglobulin family. Mavroidis, M., Sunyer, J.O., Lambris, J.D. J. Immunol. (1995) [Pubmed]
  2. Receptor-mediated transport and deposition of complement component C3 into developing chicken oocytes. Recheis, B., Rumpler, H., Schneider, W.J., Nimpf, J. Cell. Mol. Life Sci. (2005) [Pubmed]
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