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Gene Review:

NTN1 - netrin 1

Gallus gallus

Tang, F. et al., Kennedy, T.E. et al.

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High impact information on LOC396389

Axon guidance by diffusible chemoattractants: a gradient of netrin protein in the developing spinal cord [1].
In the embryonic chick spinal cord netrin-1 mRNA is expressed by floor plate cells and netrin-2 mRNA by neural epithelial cells [1].
Netrin-1 induces axon branching in developing cortical neurons by frequency-dependent calcium signaling pathways [2].
Using techniques to overexpress or suppress kinase activity, we find that calcium/calmodulin-dependent protein kinase II (CaMKII) and mitogen-activated protein kinase (MAPK) are major downstream targets of the netrin-1 calcium signaling pathway and are required for axon branching [2].

Anatomical context of LOC396389

A similar distribution of netrin-1 protein has been detected in embryonic rat and mouse spinal cord [1].

References

Axon guidance by diffusible chemoattractants: a gradient of netrin protein in the developing spinal cord. Kennedy, T.E., Wang, H., Marshall, W., Tessier-Lavigne, M. J. Neurosci. (2006) [Pubmed]
Netrin-1 induces axon branching in developing cortical neurons by frequency-dependent calcium signaling pathways. Tang, F., Kalil, K. J. Neurosci. (2005) [Pubmed]

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