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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PAICS  -  phosphoribosylaminoimidazole carboxylase,...

Gallus gallus

Synonyms: AIRC, AS
 
 
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High impact information on PAICS

  • GPAT and AIRC genes encode the enzymes that catalyze step 1 and steps 6 plus 7, respectively, in the de novo purine biosynthetic pathway [1].
 

Biological context of PAICS

  • The bidirectional promoter, embedded in a CpG island, directs coexpression of GPAT and AIRC genes from distinct transcriptional start sites 229 bp apart [1].
  • Defects in bidirectional transcription resulted from removal of an initiator-like element overlapping the AIRC transcription start site, as well as deletions removing a series of GC and CCAAT boxes from the AIRC proximal half of the promoter and a CCAAT-containing segment from the GPAT side [2].

References

  1. Coexpression of two closely linked avian genes for purine nucleotide synthesis from a bidirectional promoter. Gavalas, A., Dixon, J.E., Brayton, K.A., Zalkin, H. Mol. Cell. Biol. (1993) [Pubmed]
  2. Analysis of the chicken GPAT/AIRC bidirectional promoter for de novo purine nucleotide synthesis. Gavalas, A., Zalkin, H. J. Biol. Chem. (1995) [Pubmed]
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