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Gene Review

NAGA  -  N-acetylgalactosaminidase, alpha-

Gallus gallus

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Disease relevance of NAGA


Psychiatry related information on NAGA


High impact information on NAGA


Chemical compound and disease context of NAGA

  • The monoclonal anti-NAGA Id antibody, termed CId-1, reacted with affinity purified antibodies to NAGA, but not with antibodies specific for PABA, arsanilic acid (Ars), phosphorylcholine (PC), or with normal chicken IgG and IgM [3].

Biological context of NAGA


Associations of NAGA with chemical compounds

  • Synthesis and activity of 1-N-iminosugar inhibitors, siastatin B analogues for alpha-N-acetylgalactosaminidase and beta-N-acetylglucosaminidase [9].
  • A substitution of Trp-16 with an arginine residue in alpha-N-acetylgalactosaminidase abolished the enzyme activity, which was confirmed by replacing a 600 bp fragment containing the mutation with the corresponding wild-type sequence [10].
  • The aim of this study was to identify and characterize C. elegans orthologs to both human lysosomal luminal proteins alpha-GAL and alpha-NAGA [11].
  • By expressing site-directed mutants in the methylotrophic yeast strain Pichia pastoris, the role of a tryptophan residue at position 16 in the activity of alpha-galactosidase and alpha-N-acetylgalactosaminidase, two closely related exoglycosidases, was studied [10].

Analytical, diagnostic and therapeutic context of NAGA


  1. The 1.9 A structure of alpha-N-acetylgalactosaminidase: molecular basis of glycosidase deficiency diseases. Garman, S.C., Hannick, L., Zhu, A., Garboczi, D.N. Structure (Camb.) (2002) [Pubmed]
  2. T cell hybrids that express a VH idiotope-related determinant on a glycoprotein distinct from H-2, Thy-1, and Lyt-1 molecules. Chanh, T.C., Cooper, M.D. J. Exp. Med. (1983) [Pubmed]
  3. Mouse monoclonal antibodies to chicken VH idiotypic determinants reactivity with B and T cells. Chanh, T.C., Chen, C.L., Cooper, M.D. J. Immunol. (1982) [Pubmed]
  4. Lectin binding identifies a subpopulation of neurons in chick dorsal root ganglia. Scott, S.A., Patel, N., Levine, J.M. J. Neurosci. (1990) [Pubmed]
  5. Crystal structure of rice alpha-galactosidase complexed with D-galactose. Fujimoto, Z., Kaneko, S., Momma, M., Kobayashi, H., Mizuno, H. J. Biol. Chem. (2003) [Pubmed]
  6. Cloning and characterization of a cDNA encoding chicken liver alpha-N-acetylgalactosaminidase. Zhu, A., Goldstein, J. Gene (1993) [Pubmed]
  7. Cloning and sequence of a chicken alpha-N-acetylgalactosaminidase gene. Davis, M.O., Hata, D.J., Smith, D., Walker, J.C. Biochim. Biophys. Acta (1993) [Pubmed]
  8. Structural studies of alpha-N-acetylgalactosaminidase: effect of glycosylation on the level of expression, secretion efficiency, and enzyme activity. Zhu, A., Wang, Z.K., Beavis, R. Arch. Biochem. Biophys. (1998) [Pubmed]
  9. Synthesis and activity of 1-N-iminosugar inhibitors, siastatin B analogues for alpha-N-acetylgalactosaminidase and beta-N-acetylglucosaminidase. Nishimura, Y., Satoh, T., Kudo, T., Kondo, S., Takeuchi, T. Bioorg. Med. Chem. (1996) [Pubmed]
  10. Trp-16 is essential for the activity of alpha-galactosidase and alpha-N-acetylgalactosaminidase. Zhu, A., Monahan, C., Wang, Z.K. Biochim. Biophys. Acta (1996) [Pubmed]
  11. Characterization of gana-1, a Caenorhabditis elegans gene encoding a single ortholog of vertebrate alpha-galactosidase and alpha-N-acetylgalactosaminidase. Hujová, J., Sikora, J., Dobrovolný, R., Poupetová, H., Ledvinová, J., Kostrouchová, M., Hrebícek, M. BMC Cell Biol. (2005) [Pubmed]
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