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Gene Review:

RYR3 - ryanodine receptor 3

Sus scrofa

Giese, A. et al., Schmoelzl, S. et al., Leeb, T. et al., Leeb, T. et al.

Leeb, Giese, Al-Bayati, Rettenberger, Brenig,

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High impact information on RYR3

Three genes, i. e. ryr1, ryr2, and ryr3, have been identified coding for a skeletal muscle, cardiac muscle, and brain isoform, respectively [1].
Two highly polymorphic microsatellites within the porcine ryanodine receptor 3 gene (RYR3) [2].
Assignment of the porcine ryanodine receptor 3 gene (RYR3) to chromosome 7q22-->q23 [3].
By comparing the porcine genomic sequence to the human RYR3 cDNA sequence the porcine transcription start site could be mapped to a GC-rich region [4].
We isolated eight overlapping PAC clones from the porcine ryanodine receptor 3 gene (RYR3) and determined the DNA sequences of the first and second exon together with 5.8 kb of 5' flanking region and 10.3 kb of intron sequences [4].

Anatomical context of RYR3

Ryanodine receptor 3 is a calcium channel located in the membrane of the endoplasmic reticulum [4].

References

Regulation of tissue-specific expression of the skeletal muscle ryanodine receptor gene. Schmoelzl, S., Leeb, T., Brinkmeier, H., Brem, G., Brenig, B. J. Biol. Chem. (1996) [Pubmed]
Two highly polymorphic microsatellites within the porcine ryanodine receptor 3 gene (RYR3). Leeb, T., Giese, A., Pfeiffer, I., Brenig, B. Anim. Genet. (1999) [Pubmed]
Assignment of the porcine ryanodine receptor 3 gene (RYR3) to chromosome 7q22-->q23. Leeb, T., Giese, A., Al-Bayati, H., Rettenberger, G., Brenig, B. Cytogenet. Cell Genet. (1998) [Pubmed]
Genomic structure of the 5' end of the porcine ryanodine receptor 3 gene (RYR3). Giese, A., Deppe, A., Brenig, B., Leeb, T. DNA Seq. (2000) [Pubmed]

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