Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

GDF11 - growth differentiation factor 11

Sus scrofa

Nakashima, M. et al., Nakashima, M. et al.

Nakashima, Tachibana, Iohara, Ito, Ishikawa, Akamine, Nakashima, Iohara, Ishikawa, Ito, Tomokiyo, Tanaka, Akamine,

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High impact information on GDF11

To develop a successful ex vivo gene therapy to induce reparative dentin formation rapidly and effectively after treatment of caries, we developed a three-dimensional pellet culture system of pulp cells electrotransfected with growth/differentiation factor 11 (Gdf11) [1].
Stimulation of reparative dentin formation by ex vivo gene therapy using dental pulp stem cells electrotransfected with growth/differentiation factor 11 (Gdf11) [1].
The transfection of Gdf11 by sonoporation stimulated a large amount of reparative dentin formation on the amputated dental pulp in canine teeth in vivo [2].

Biological context of GDF11

The Gdf11 cDNA plasmid transferred into dental pulp tissue by sonoporation in vitro, induced the expression of dentin sialoprotein (Dsp), a differentiation marker for odontoblasts [2].

Analytical, diagnostic and therapeutic context of GDF11

Thus, Gdf11 gene therapy may be potentially used in endodontic treatment in dentistry [1].

References

Stimulation of reparative dentin formation by ex vivo gene therapy using dental pulp stem cells electrotransfected with growth/differentiation factor 11 (Gdf11). Nakashima, M., Iohara, K., Ishikawa, M., Ito, M., Tomokiyo, A., Tanaka, T., Akamine, A. Hum. Gene Ther. (2004) [Pubmed]
Induction of reparative dentin formation by ultrasound-mediated gene delivery of growth/differentiation factor 11. Nakashima, M., Tachibana, K., Iohara, K., Ito, M., Ishikawa, M., Akamine, A. Hum. Gene Ther. (2003) [Pubmed]

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