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TGFA  -  transforming growth factor, alpha

Sus scrofa

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Disease relevance of TGFA


High impact information on TGFA


Biological context of TGFA


Anatomical context of TGFA


Associations of TGFA with chemical compounds


Regulatory relationships of TGFA

  • These data show that TGF-alpha inhibits gastric acid secretion in a manner similar to EGF and that the two growth factors share at least one physiological action unrelated to their mitogenic properties [4].
  • EGF and TGF alpha (5 ng/mL each) enhanced TGF beta 1 mRNA about threefold within 4 and 8 hours [15].

Other interactions of TGFA


Analytical, diagnostic and therapeutic context of TGFA


  1. Epithelial wound healing enhanced by transforming growth factor-alpha and vaccinia growth factor. Schultz, G.S., White, M., Mitchell, R., Brown, G., Lynch, J., Twardzik, D.R., Todaro, G.J. Science (1987) [Pubmed]
  2. Oral transforming growth factor-alpha enhances jejunal mucosal recovery and electrical resistance in piglet rotavirus enteritis. Rhoads, J.M., Ulshen, M.H., Keku, E.O., Chen, W., Kandil, H.M., Woodard, J.P., Liu, S.C., Fuller, C.R., Leary, H.L., Lecce, J.G. Pediatr. Res. (1995) [Pubmed]
  3. Transforming growth factor alpha inhibits glycogen synthesis and counteracts the stimulation by insulin in hepatocytes. Peak, M., Agius, L. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  4. Transforming growth factor alpha inhibits secretion of gastric acid. Rhodes, J.A., Tam, J.P., Finke, U., Saunders, M., Bernanke, J., Silen, W., Murphy, R.A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  5. Expression of the genes for TGF alpha, EGF and the EGF receptor during early pig development. Vaughan, T.J., James, P.S., Pascall, J.C., Brown, K.D. Development (1992) [Pubmed]
  6. Molecular cloning and tissue distribution of pig transforming growth factor alpha. Vaughan, T.J., James, P.S., Pascall, J.C., Brown, K.D. Biochem. J. (1993) [Pubmed]
  7. Hydrolysis of transforming growth factor-alpha by cell-surface peptidases in vitro. Choudry, Y., Kenny, A.J. Biochem. J. (1991) [Pubmed]
  8. Cellular distribution of EGF, TGFalpha and their receptor during postnatal development and spermatogenesis of the boar testis. Caussanel, V., Tabone, E., Mauduit, C., Dacheux, F., Benahmed, M. Mol. Cell. Endocrinol. (1996) [Pubmed]
  9. Glycerophosphorylethanolamine (GPEA) identified as an hepatocyte growth stimulator in liver extracts. Nelson, C., Moffat, B., Jacobsen, N., Henzel, W.J., Stults, J.T., King, K.L., McMurtrey, A., Vandlen, R., Spencer, S.A. Exp. Cell Res. (1996) [Pubmed]
  10. Ligand binding characterization and molecular analysis of distinct epidermal growth factor-urogastrone receptors in cultured smooth muscle and epithelial cells from guinea pig intestine. Yang, S.G., Ahmad, S., Wong, N.C., Hollenberg, M.D. Mol. Pharmacol. (1994) [Pubmed]
  11. Epidermal growth factor regulates the transition from basal sodium absorption to anion secretion in cultured endometrial epithelial cells. Deachapunya, C., O'Grady, S.M. J. Cell. Physiol. (2001) [Pubmed]
  12. L-glutamine and transforming growth factor-alpha enhance recovery of monoacylglycerol acyltransferase and diacylglycerol acyltransferase activity in porcine postischemic ileum. Ahdieh, N., Blikslager, A.T., Bhat, B.G., Coleman, R.A., Argenzio, R.A., Rhoads, J.M. Pediatr. Res. (1998) [Pubmed]
  13. Tyrosine kinase inhibitors and the contractile action of epidermal growth factor-urogastrone and other agonists in gastric smooth muscle. Yang, S.G., Saifeddine, M., Hollenberg, M.D. Can. J. Physiol. Pharmacol. (1992) [Pubmed]
  14. Roles of cytoskeleton and tyrosine receptor mediated signal transduction in the restitution of isolated guinea pig gastric mucosa. Bhowmik, A., Paimela, H., Mustonen, H., Kivilaakso, E. Scand. J. Gastroenterol. (2002) [Pubmed]
  15. Regulation of transforming growth factor beta 1 messenger ribonucleic acid expression in porcine thyroid follicles in vitro by growth factors, iodine, or delta-iodolactone. Gărtner, R., Schopohl, D., Schaefer, S., Dugrillon, A., Erdmann, A., Toda, S., Bechtner, G. Thyroid (1997) [Pubmed]
  16. Modulation of transforming growth factor-beta 1 stimulated elastin and collagen production and proliferation in porcine vascular smooth muscle cells and skin fibroblasts by basic fibroblast growth factor, transforming growth factor-alpha, and insulin-like growth factor-I. Davidson, J.M., Zoia, O., Liu, J.M. J. Cell. Physiol. (1993) [Pubmed]
  17. Identification of genes expressed in the epithelium of porcine oviduct containing early embryos at various stages of development. Chang, H.S., Cheng, W.T., Wu, H.K., Choo, K.B. Mol. Reprod. Dev. (2000) [Pubmed]
  18. Identification of an EGF/TGF-alpha receptor in primary cultures of guinea pig gastric mucous epithelial cells. Rutten, M.J., Dempsey, P.J., Luttropp, C.A., Hawkey, M.A., Sheppard, B.C., Crass, R.A., Deveney, C.W., Coffey, R.J. Am. J. Physiol. (1996) [Pubmed]
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