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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

FN1  -  fibronectin 1

Sus scrofa

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Disease relevance of FN1


High impact information on FN1


Chemical compound and disease context of FN1


Biological context of FN1


Anatomical context of FN1

  • A provisional stromal matrix of cross-linked fibrin and fibronectin was initially deposited in both tumors and wounds and was subsequently replaced by granulation tissue containing collagen types I and III [18].
  • Fibronectin mediates the attachment of fibroblasts but not of epidermal cells to collagen [19].
  • Megakaryocytes spread with an active ruffled membrane in response to ADP (1-100 microM), thrombin (1.0 U/ml), and arachidonic acid (50 microM) but responded to collagen surfaces only if fibronectin was added to the cultures [20].
  • Fibronectin-containing microfibrils link fibroblasts to each other and to collagen bundles and thereby provide transduction cables across the wound for contraction [21].
  • Endothelial cell fibronectin synthesis was determined after radiolabeling with [35S]-methionine in serum-free medium, gelatin-sepharose extraction of the culture medium and resolution on 5% SDS-PAGE [22].

Associations of FN1 with chemical compounds


Physical interactions of FN1


Regulatory relationships of FN1


Other interactions of FN1

  • To investigate the mechanism of action of p38 MAPK, we explored its cellular localization and that of its indirect substrate, the heat shock protein Hsp27, during SMC spreading on fibronectin in the presence and absence of PDGF [29].
  • In contrast, mRNA levels coding for type I collagen, fibronectin and GAPDH (used as control of cellular activity) were not modified [30].
  • Therefore, basic protein BHB-2 belongs to a new family of DQH sperm surface proteins that are homologous to the acidic proteins from bull and stallion seminal plasma, to the collagen binding domain II in fibronectin and to the leucocyte cell-cell adhesion regulator, but are not homologous to AQN or AWN spermadhesins [31].
  • Immunohistochemical staining to desmosomal proteins, cellular fibronectin, laminin 1, laminin 5, collagen IV, collagen VII, p53, Bcl-2, and PCNA was performed on weanling pig skin exposed to vesicating doses of HD, GB3, an antibody to laminin 5, showed a progressive decrease with loss of expression during the time period of clinical vesiculation [32].
  • In lavage, only SP-D, alpha (2)-macroglobulin and fibronectin were detected [33].

Analytical, diagnostic and therapeutic context of FN1


  1. Adoptive immunity to the guinea pig line 10 hepatoma and the nature of in vitro lymphoid-tumor cell interactions. Shu, S., Steerenberg, P.A., Hunter, J.T., Evans, C.H., Rapp, H.J. Cancer Res. (1981) [Pubmed]
  2. Fibronectin receptors from Streptococcus dysgalactiae and Staphylococcus aureus. Involvement of conserved residues in ligand binding. McGavin, M.J., Gurusiddappa, S., Lindgren, P.E., Lindberg, M., Raucci, G., Höök, M. J. Biol. Chem. (1993) [Pubmed]
  3. Fibronectin is the major fibroblast chemoattractant in rabbit anti-glomerular basement membrane disease. Gharaee-Kermani, M., Wiggins, R., Wolber, F., Goyal, M., Phan, S.H. Am. J. Pathol. (1996) [Pubmed]
  4. Humoral response in Treponema pallidum-infected guinea pigs. II. Circulating immune complexes and autoimmune responses. Baughn, R.E., Wicher, V., Jakubowski, A., Wicher, K. J. Immunol. (1987) [Pubmed]
  5. Modulation of expression of delayed hypersensitivity by mycobacterial antigen 85 fibronectin-binding proteins. Godfrey, H.P., Feng, Z., Mandy, S., Mandy, K., Huygen, K., De Bruyn, J., Abou-Zeid, C., Wiker, H.G., Nagai, S., Tasaka, H. Infect. Immun. (1992) [Pubmed]
  6. Monocyte receptors for fibronectin characterized by a monoclonal antibody that interferes with receptor activity. Hosein, B., Bianco, C. J. Exp. Med. (1985) [Pubmed]
  7. Clusterin promotes the aggregation and adhesion of renal porcine epithelial cells. Silkensen, J.R., Skubitz, K.M., Skubitz, A.P., Chmielewski, D.H., Manivel, J.C., Dvergsten, J.A., Rosenberg, M.E. J. Clin. Invest. (1995) [Pubmed]
  8. Upregulation of fibronectin synthesis by interleukin-1 beta in coronary artery smooth muscle cells is associated with the development of the post-cardiac transplant arteriopathy in piglets. Clausell, N., Rabinovitch, M. J. Clin. Invest. (1993) [Pubmed]
  9. Induction of fibronectin-binding proteins and increased adhesion of quinolone-resistant Staphylococcus aureus by subinhibitory levels of ciprofloxacin. Bisognano, C., Vaudaux, P., Rohner, P., Lew, D.P., Hooper, D.C. Antimicrob. Agents Chemother. (2000) [Pubmed]
  10. Inhibition by heparin and derivatized dextrans of Staphylococcus epidermidis adhesion to in vitro fibronectin-coated or explanted polymer surfaces. Francois, P., Letourneur, D., Lew, D.P., Jozefonwicz, J., Vaudaux, P. Journal of biomaterials science. Polymer edition. (1999) [Pubmed]
  11. Indirect immunohistochemistry and immunoelectron microscopy distribution of eight epidermal-dermal junction epitopes in the pig and in isolated perfused skin treated with bis (2-chloroethyl) sulfide. Monteiro-Riviere, N.A., Inman, A.O. Toxicologic pathology. (1995) [Pubmed]
  12. Effects of a novel Mac-1 inhibitor, NPC 15669, on hemostatic parameters during preconditioned myocardial infarction. Serebruany, V.L., Yurovsky, V.V., Gurbel, P.A. Life Sci. (1999) [Pubmed]
  13. Comparison of triphenyltetrazolium chloride (TTC) staining versus detection of fibronectin in experimental myocardial infarction. Holmbom, B., Näslund, U., Eriksson, A., Virtanen, I., Thornell, L.E. Histochemistry (1993) [Pubmed]
  14. Localization of a cryptic binding site for tenascin on fibronectin. Ingham, K.C., Brew, S.A., Erickson, H.P. J. Biol. Chem. (2004) [Pubmed]
  15. Fibronectin promotes epithelial migration of cultured rabbit cornea in situ. Nishida, T., Nakagawa, S., Awata, T., Ohashi, Y., Watanabe, K., Manabe, R. J. Cell Biol. (1983) [Pubmed]
  16. In vivo co-distribution of fibronectin and actin fibers in granulation tissue: immunofluorescence and electron microscope studies of the fibronexus at the myofibroblast surface. Singer, I.I., Kawka, D.W., Kazazis, D.M., Clark, R.A. J. Cell Biol. (1984) [Pubmed]
  17. Extracellular matrix alters PDGF regulation of fibroblast integrins. Xu, J., Clark, R.A. J. Cell Biol. (1996) [Pubmed]
  18. Pathogenesis of desmoplasia. I. Immunofluorescence identification and localization of some structural proteins of line 1 and line 10 guinea pig tumors and of healing wounds. Dvorak, H.F., Form, D.M., Manseau, E.J., Smith, B.D. J. Natl. Cancer Inst. (1984) [Pubmed]
  19. Epidermal cells adhere preferentially to type IV (basement membrane) collagen. Murray, J.C., Stingl, G., Kleinman, H.K., Martin, G.R., Katz, S.I. J. Cell Biol. (1979) [Pubmed]
  20. Cultured megakaryocytes: changes in the cytoskeleton after ADP-induced spreading. Leven, R.M., Nachmias, V.T. J. Cell Biol. (1982) [Pubmed]
  21. Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction. Welch, M.P., Odland, G.F., Clark, R.A. J. Cell Biol. (1990) [Pubmed]
  22. Coronary artery endothelial interleukin-1 beta mediates enhanced fibronectin production related to post-cardiac transplant arteriopathy in piglets. Molossi, S., Clausell, N., Rabinovitch, M. Circulation (1993) [Pubmed]
  23. Tenascin-C binds heparin by its fibronectin type III domain five. Weber, P., Zimmermann, D.R., Winterhalter, K.H., Vaughan, L. J. Biol. Chem. (1995) [Pubmed]
  24. Sinusoidal endothelial cells from guinea pig liver synthesize and secrete cellular fibronectin in vitro. Rieder, H., Ramadori, G., Dienes, H.P., Meyer zum Büschenfelde, K.H. Hepatology (1987) [Pubmed]
  25. Morphologic and immunofluorescence studies of the effect of fibroblast growth factor on the culture of guinea pig glomerular cell strains. Oberley, T.D., Murphy-Ullrich, J.E., Muth, J.V. Am. J. Pathol. (1981) [Pubmed]
  26. Isolation and characterization of glycine-rich gelatin-binding protein, a plasma glycoprotein which interacts with gelatin, arginine, heparin, and hyaluronic acid. Isemura, M., Sato, N., Yosizawa, Z. J. Biol. Chem. (1982) [Pubmed]
  27. Reciprocal induction of tumor necrosis factor-alpha and interleukin-1 beta activity mediates fibronectin synthesis in coronary artery smooth muscle cells. Molossi, S., Clausell, N., Rabinovitch, M. J. Cell. Physiol. (1995) [Pubmed]
  28. The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases. Stanton, H., Ung, L., Fosang, A.J. Biochem. J. (2002) [Pubmed]
  29. Control of actin dynamics by p38 MAP kinase - Hsp27 distribution in the lamellipodium of smooth muscle cells. Pichon, S., Bryckaert, M., Berrou, E. J. Cell. Sci. (2004) [Pubmed]
  30. Expression of fibronectin and interstitial collagen genes in smooth muscle cells: modulation by low molecular weight heparin fragments and serum. Asselot-Chapel, C., Combacau, L., Labat-Robert, J., Kern, P. Biochem. Pharmacol. (1995) [Pubmed]
  31. Spermadhesins of the AQN and AWN families, DQH sperm surface protein and HNK protein in the heparin-binding fraction of boar seminal plasma. Jonáková, V., Kraus, M., Veselský, L., Cechová, D., Bezouska, K., Tichá, M. J. Reprod. Fertil. (1998) [Pubmed]
  32. Immunohistochemical studies of basement membrane proteins and proliferation and apoptosis markers in sulfur mustard induced cutaneous lesions in weanling pigs. Smith, K.J., Graham, J.S., Hamilton, T.A., Skelton, H.G., Petrali, J.P., Hurst, C.G. J. Dermatol. Sci. (1997) [Pubmed]
  33. Plasma C3d levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings. Hoffmann, H.J., Iversen, M., Brandslund, I., Sigsgaard, T., Omland, Ø., Oxvig, C., Holmskov, U., Bjermer, L., Jensenius, J.C., Dahl, R. Annals of agricultural and environmental medicine : AAEM. (2003) [Pubmed]
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