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Gene Review:

cdc25c-b - cell division cycle 25C

Xenopus laevis

Synonyms: cdc25, cdc25-1-b, cdc25C2, cdc25c, xcdc25c

Nagata, S. et al., Kumagai, A. et al., Sakuta, H., Ippolito, D.L. et al., Wischmeyer, E. et al., et al.

Nagata, Saito, Yamada, Fujita, Watanabe,

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Disease relevance of cdc25C2

Although phenylarsine oxide (1-100 microM), a putative inhibitor of protein tyrosine phosphatase, also facilitated the K+ currents, the current enhancing effects were not affected by pertussis toxin [1].

High impact information on cdc25C2

Moreover, treatment of interphase Xenopus extracts with okadaic acid, a phosphatase inhibitor that accelerates the entry into mitosis, elicits both the premature hyperphosphorylation of cdc25 and the stimulation of its cdc2-specific tyrosine phosphatase activity [2].
Tyrosine phosphatase inhibition by peroxyvanadate pretreatment reversibly mimicked the BDNF/trkB effect, indicating that tyrosine phosphorylation of Kir3 may have caused the GTPase acceleration [3].
Native Kir2.1 channels in rat basophilic leukocytes were affected by manipulation of the TK and protein tyrosine phosphatase activity in a qualitatively similar manner [4].
Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase [5].
Multiple variants of receptor-type protein tyrosine phosphatase beta are expressed in the central nervous system of Xenopus [6].

Biological context of cdc25C2

We have isolated cDNA clones encoding the Xenopus homologue of receptor-type protein tyrosine phosphatase beta (RPTPbeta), and identified 13 forms of the mRNA provably generated by alternative splicing [6].

Anatomical context of cdc25C2

Alkaline phosphatase but not a protein tyrosine phosphatase, when injected into oocytes, reduced GABA(A) receptor membrane expression [7].

References

Potentiation by insulin and insulin-like growth factor-1 of glibenclamide-sensitive K+ currents in follicle-enclosed Xenopus oocytes. Sakuta, H. Eur. J. Pharmacol. (1994) [Pubmed]
Regulation of the cdc25 protein during the cell cycle in Xenopus extracts. Kumagai, A., Dunphy, W.G. Cell (1992) [Pubmed]
N-terminal tyrosine residues within the potassium channel Kir3 modulate GTPase activity of Galphai. Ippolito, D.L., Temkin, P.A., Rogalski, S.L., Chavkin, C. J. Biol. Chem. (2002) [Pubmed]
Acute suppression of inwardly rectifying Kir2.1 channels by direct tyrosine kinase phosphorylation. Wischmeyer, E., Döring, F., Karschin, A. J. Biol. Chem. (1998) [Pubmed]
Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase. Holland, W., Morrison, T., Chang, Y., Wiernsperger, N., Stith, B.J. Biochem. Pharmacol. (2004) [Pubmed]
Multiple variants of receptor-type protein tyrosine phosphatase beta are expressed in the central nervous system of Xenopus. Nagata, S., Saito, R., Yamada, Y., Fujita, N., Watanabe, K. Gene (2001) [Pubmed]
Confocal microscopic study of GABA(A) receptors in Xenopus oocytes after rat brain mRNA injection: modulation by tyrosine kinase activity. Balduzzi, R., Cupello, A., Diaspro, A., Ramoino, P., Robello, M. Biochim. Biophys. Acta (2001) [Pubmed]

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