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Gene Review:

gipc1 - GIPC PDZ domain containing family, member 1

Xenopus laevis

Synonyms: GIPC, XGIPC, kermit

Tan, C. et al., Wu, J. et al.

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High impact information on Kermit

A constitutively active PI3 kinase partially rescues the Kermit 2/XGIPC loss-of-function phenotype [1].
Our results provide the first in vivo loss of function analysis of GIPC in embryonic development and also indicate that kermit 2/XGIPC is a novel component of the IGF pathway, potentially functioning through modulation of the IGF1 receptor [1].
These observations suggest that Kermit is required for Wnt/frizzled signaling in neural crest development [2].
Co-expression of Xfz3 and Kermit results in a dramatic translocation of Kermit to the plasma membrane [2].
Inhibition of Kermit function with morpholino antisense oligonucleotides directed against the 5' untranslated region of Kermit mRNA blocks neural crest induction by Xfz3, and this is rescued by co-injection of mRNA encoding the Kermit open reading frame [2].

References

Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development. Wu, J., O'donnell, M., Gitler, A.D., Klein, P.S. Development (2006) [Pubmed]
Kermit, a frizzled interacting protein, regulates frizzled 3 signaling in neural crest development. Tan, C., Deardorff, M.A., Saint-Jeannet, J.P., Yang, J., Arzoumanian, A., Klein, P.S. Development (2001) [Pubmed]

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