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Gene Review:

smo - smoothened

Xenopus laevis

DeCamp, D.L. et al., Zhang, J. et al.

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Disease relevance of Smo

The mutation W535L (SmoM2) in human Smo is associated with basal cell skin cancers, causes constitutive, ligand-independent signaling through the Hedgehog pathway, and provides a powerful means to test effects of unregulated Hedgehog signaling [1].
Smoothened-mediated pigment aggregation was reversed by treatment with pertussis toxin or by co-expression with dominant negative Galpha(i) [2].

High impact information on Smo

Sonic hedgehog reversed Patched-mediated inhibition of Smoothened and induced pigment aggregation [2].
Smoothened activates Galphai-mediated signaling in frog melanophores [2].
Patched blocked Smoothened-mediated melanosome aggregation in a dose-dependent manner, consistent with its physiological role as an inhibitor of Smoothened [2].

References

Downregulation of Hedgehog signaling is required for organogenesis of the small intestine in Xenopus. Zhang, J., Rosenthal, A., de Sauvage, F.J., Shivdasani, R.A. Dev. Biol. (2001) [Pubmed]
Smoothened activates Galphai-mediated signaling in frog melanophores. DeCamp, D.L., Thompson, T.M., de Sauvage, F.J., Lerner, M.R. J. Biol. Chem. (2000) [Pubmed]

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