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Gene Review:

bolA - transcriptional regulator BolA

Escherichia coli UTI89

Koch, B. et al., Freire, P. et al.

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Disease relevance of bolA

The RpoS-regulated bolA gene in Escherichia coli is important for the decrease in cell size during stationary phase or sudden carbon starvation [1].
Initial characterization of a bolA homologue from Pseudomonas fluorescens indicates different roles for BolA-like proteins in P. fluorescens and Escherichia coli [1].

High impact information on bolA

A Pseudomonas fluorescens strain mutated in a gene with homology to bolA reduced its cell size upon carbon starvation, and RpoS had little effect on bolA expression [1].
Reverse transcriptase polymerase chain reaction analysis indicated that the bolA homologue is the second gene in an operon where the two next ORFs encode putative proteins with homology to sulphurtransferases and protein disulphide isomerases [1].
Escherichia coli bolA is a morphogene involved in stress response and cell division [2].

References

Initial characterization of a bolA homologue from Pseudomonas fluorescens indicates different roles for BolA-like proteins in P. fluorescens and Escherichia coli. Koch, B., Nybroe, O. FEMS Microbiol. Lett. (2006) [Pubmed]
Effect of the morphogene bolA on the permeability of the Escherichia coli outer membrane. Freire, P., Vieira, H.L., Furtado, A.R., de Pedro, M.A., Arraiano, C.M. FEMS Microbiol. Lett. (2006) [Pubmed]

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