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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

wnt8b  -  wingless-type MMTV integration site family...

Xenopus laevis

Synonyms: wnt-8b, xwnt-8b, xwnt8b
 
 
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High impact information on Xwnt-8b

  • These signaling defects can be restored by the addition of beta-catenin but not Xwnt8b [1].
  • During early cleavage stages Xwnt-8b transcripts are confined primarily to animal hemisphere blastomeres, while zygotically derived Xwnt-8b transcripts are restricted almost exclusively to a band of cells in the prospective forebrain of neurula and tailbud stage embryos [2].
  • Both maternal and zygotic Xwnt-8b transcripts undergo alternative splicing to generate mRNAs which encode two different forms of Xwnt-8b protein [2].
  • After the primary anterior-posterior patterning of the neural plate, a subset of wnt signaling molecules including Xwnt-1, Xwnt-2b, Xwnt-3A, Xwnt-8b are still expressed in the developing brain in a region spanning from the posterior part of the diencephalon to the mesencephalon/metencephalon boundary [3].
  • Coexpression of Xwnt-8b along with Vg1 restores ectodermal competence to form notochord [4].
 

Anatomical context of Xwnt-8b

  • While ectopically expressed Xwnt-8b can substitute for the dorsalizing signals activated in either ectoderm or endoderm, and can allow notochord formation in recombinants, Vg1 alone is not sufficient to induce notochord in ectodermal explants in the absence of signals activated by cortical rotation [4].

References

 
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