Gene Review:
pyrI - aspartate carbamoyltransferase
Escherichia coli UTI89
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Disease relevance of pyrI
High impact information on pyrI
- Molecular cloning and subsequent DNA analysis demonstrated that the pyrB and pyrI genes are contiguous with pyrI as the distal gene in the operon [1].
- Evidence for this single transcriptional unit was obtained by a study of various deletion mutations and from the DNA sequence of the intercistronic region between pyrB and pyrI [1].
- The cistrons are separated by a 15-nucleotide untranslated region containing a sequence capable of interacting with the 16S ribosomal RNA and allowing translation of the pyrI cistron [1].
References
- Genes encoding Escherichia coli aspartate transcarbamoylase: the pyrB-pyrI operon. Pauza, C.D., Karels, M.J., Navre, M., Schachman, H.K. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
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