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Gene Review

cnbp  -  CCHC-type zinc finger, nucleic acid...

Xenopus laevis

Synonyms: cnbp1, cnbpa, dm2, promm, rnf163, ...
 
 
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Disease relevance of CNBP

 

High impact information on CNBP

  • Recently, we found that two proteins, the Xenopus laevis La autoantigen and the cellular nucleic acid binding protein (CNBP), are able to bind in vitro a pyrimidine tract at the 5' end and a downstream region, respectively [2].
  • The polysome association of CNBP mRNA and the binding activity of CNBP to its target sequence of ribosomal protein mRNA 5'UTR have been analysed during development [3].
  • However, the shorter CNBP transcripts are slightly less represented than the longer CNBP transcripts, in both the oocyte and embryo [3].
  • The generic TCS configuration consists of a plasmid encoding CNBP or La under control of the tetracycline-responsive expression system (TET(OFF)) and a target expression vector containing a TOP module between a constitutive P(SV40) promoter and the human model product gene SEAP (human secreted alkaline phosphatase) (P(SV40)-TOP-SEAP-pA) [4].
  • Alternatively to CNBP and La, TOP-mediated translation control can also be adjusted by artificial phosphorothioate anti-TOP oligodeoxynucleotides [4].
 

Biological context of CNBP

  • CNBP and La exemplify for the first time the potential of RNA-binding proteins to exert translation control of desired transgenes and to increase heterologous protein production in mammalian cells [4].
 

Analytical, diagnostic and therapeutic context of CNBP

References

 
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