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Gene Review:

lacI - lac repressor

Escherichia coli UTI89

Good, L. et al., Tang, M.L. et al.

Good, Sandberg, Larsson, Nielsen, Wahlestedt,

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Disease relevance of lacI

Mutational spectrum of the lacI gene in Escherichia coli K12 induced by low-energy ion beam [1].

High impact information on lacI

To evaluate the importance of such cellular factors on PNA effects, the authors developed a positive assay for antisense inhibition by targeting the lac operon repressor and compared PNA susceptibilities in mutant and wild-type E. coli by assessing lacZ induction [2].

References

Mutational spectrum of the lacI gene in Escherichia coli K12 induced by low-energy ion beam. Tang, M.L., Wang, S.C., Wang, T., Zhao, S.G., Wu, Y.J., Wu, L.J., Yu, Z.L. Mutat. Res. (2006) [Pubmed]
Antisense PNA effects in Escherichia coli are limited by the outer-membrane LPS layer. Good, L., Sandberg, R., Larsson, O., Nielsen, P.E., Wahlestedt, C. Microbiology (Reading, Engl.) (2000) [Pubmed]

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