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Gene Review

pyrD  -  dihydroorotate dehydrogenase 2

Escherichia coli UTI89

 
 
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Disease relevance of pyrD

 

High impact information on pyrD

  • Dihydroorotate dehydrogenase catalyzes the oxidation of dihydroorotate to orotate [1].
  • Here we have cloned, overexpressed, purified, and characterized the product of the gene from LmjF chromosome 16: LmjF16.0530, which encodes a protein with putative dihydroorotate dehydrogenase activity [2].
  • In this study we investigated C. albicans dihydroorotate dehydrogenase (DHODH, EC 1.3.99.11), which catalyzes the fourth step of de novo pyrimidine synthesis, as a new target for controlling infection [3].

References

 
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