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VWA5A  -  von Willebrand factor A domain containing 5A

Homo sapiens

Synonyms: BCSC-1, BCSC1, Breast cancer suppressor candidate 1, LOH11CR2A, Loss of heterozygosity 11 chromosomal region 2 gene A protein, ...
 
 
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Disease relevance of LOH11CR2A

  • METHODS: We analyzed data on 653 833 mammograms from 540 738 women between 40 and 84 years of age who underwent screening mammography at facilities participating in the National Cancer Institute's Breast Cancer Surveillance Consortium (BCSC) throughout 1996 and 1997 [1].
  • CONCLUSION: Periodic skin examinations appear well justified after removal of BCSC to detect new skin cancers including melanoma [2].
  • BACKGROUND: Persons with basal cell skin cancer (BCSC) have shown increased risk of developing cancer at several other sites [2].
  • RESULTS: In retrospective follow-up for up to 24 years (mean 11.3 years), BCSC patients experienced statistically significant increases in the incidence of all cancer (relative risk [RR] = 1.2, 95% confidence interval [CI] = 1.1-1.4) lung cancer (RR = 1.4, CI = 1.0-1.8) and melanoma (RR = 2.2, CI = 1.6-3.0) [2].
 

High impact information on LOH11CR2A

References

  1. Detection of ductal carcinoma in situ in women undergoing screening mammography. Ernster, V.L., Ballard-Barbash, R., Barlow, W.E., Zheng, Y., Weaver, D.L., Cutter, G., Yankaskas, B.C., Rosenberg, R., Carney, P.A., Kerlikowske, K., Taplin, S.H., Urban, N., Geller, B.M. J. Natl. Cancer Inst. (2002) [Pubmed]
  2. Association of basal cell skin cancers with other cancers (United States). Friedman, G.D., Tekawa, I.S. Cancer Causes Control (2000) [Pubmed]
  3. Molecular cloning and characterization of LOH11CR2A, a new gene within a refined minimal region of LOH at 11q23. Monaco, C., Negrini, M., Sozzi, G., Veronese, M.L., Vorechovsky, I., Godwin, A.K., Croce, C.M. Genomics (1997) [Pubmed]
 
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