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Gene Review

ectC  -  L-ectoine synthase

Chromohalobacter salexigens DSM 3043

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Disease relevance of Csal_1878

  • Strain CHR63 is a salt-sensitive mutant of the moderately halophilic wild-type strain Halomonas elongata DSM 3043 that is affected in the ectoine synthase gene (ectC) [1].
  • The addition of NADA-containing extracts of an ectoine synthase mutant of the broad salt-growing halophile Chromohalobacter salexigens DSM 3043(T) could alleviate the inhibitory effects of high salinity in S. enterica, which lacks the ectoine biosynthetic pathway [2].

Associations of Csal_1878 with chemical compounds

  • This mutant accumulated ectoine and hydroxyectoine as major compatible solutes, but also the ectoine precursor, N-gamma-acetyldiaminobutyric acid, and was found to be affected in the ectoine synthase gene ectC [3].


  1. Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine. Cánovas, D., Borges, N., Vargas, C., Ventosa, A., Nieto, J.J., Santos, H. Appl. Environ. Microbiol. (1999) [Pubmed]
  2. Osmoprotection of Salmonella enterica serovar Typhimurium by N(gamma)-acetyldiaminobutyrate, the precursor of the compatible solute ectoine. Garc??a-Estepa, R., C??novas, D., Iglesias-Guerra, F., Ventosa, A., Csonka, L.N., Nieto, J.J., Vargas, C. Syst. Appl. Microbiol. (2006) [Pubmed]
  3. Contribution of chemical changes in membrane lipids to the osmoadaptation of the halophilic bacterium Chromohalobacter salexigens. Vargas, C., Kallimanis, A., Koukkou, A.I., Calderon, M.I., Canovas, D., Iglesias-Guerra, F., Drainas, C., Ventosa, A., Nieto, J.J. Syst. Appl. Microbiol. (2005) [Pubmed]
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