Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

vegfc - vascular endothelial growth factor c

Danio rerio

Synonyms: SO:0000704

Küchler, A.M. et al., Ober, E.A. et al.

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High impact information on vegfc

Development of the zebrafish lymphatic system requires VEGFC signaling [1].
We demonstrate the existence of vessels that are molecularly and functionally distinct from blood vessels and show that the development of these vessels depends on Vegfc and VEGFR-3/Flt4 signaling [1].
Vegfc is required for vascular development and endoderm morphogenesis in zebrafish [2].

Anatomical context of vegfc

Further analyses indicate that Vegfc is additionally required for the initial formation of the dorsal endoderm [2].

References

Development of the zebrafish lymphatic system requires VEGFC signaling. Küchler, A.M., Gjini, E., Peterson-Maduro, J., Cancilla, B., Wolburg, H., Schulte-Merker, S. Curr. Biol. (2006) [Pubmed]
Vegfc is required for vascular development and endoderm morphogenesis in zebrafish. Ober, E.A., Olofsson, B., Mäkinen, T., Jin, S.W., Shoji, W., Koh, G.Y., Alitalo, K., Stainier, D.Y. EMBO Rep. (2004) [Pubmed]

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