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MET  -  met proto-oncogene (hepatocyte growth...

Canis lupus familiaris

 
 
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High impact information on MET

  • A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis [1].
  • SF/HGF is the ligand of the c-Met receptor tyrosine kinase [1].
  • (iv) The separate heavy chain as well as a naturally occurring splice variant consisting of the N terminus and the first two kringle domains bound the c-Met receptor, stimulated tyrosine auto-phosphorylation, and induced scattering of epithelial cells but not mitogenesis [1].
  • Src homology 2-containing inositol 5-phosphatase 1 binds to the multifunctional docking site of c-Met and potentiates hepatocyte growth factor-induced branching tubulogenesis [2].
  • Because a number of signaling molecules such as Grb2, phosphatidylinositol 3-kinase, and Gab1 bind to the multifunctional docking site, we further performed an in vitro competition study using glutathione S-transferase- or His-tagged signaling molecules with c-Met tyrosine kinase [2].
 

Biological context of MET

 

Anatomical context of MET

  • The blebbing response was dependent on autocrine HGF (hepatocyte growth factor) activation of c-Met and prevented by inhibition of RhoA, ROCK and p38 MAPK (p38 mitogen-activated protein kinase), but not ERK (extracellular-signal-regulated kinase) or PI3K (phosphoinositide 3-kinase) [5].
  • BACKGROUND INFORMATION: The c-Met-dependent, beta-actin-rich, blebbed pseudopodia of MSV-MDCK-INV (invasive Moloney-sarcoma-virus-transformed Madin-Darby canine kidney) cells are induced by Rho/ROCK (Rho kinase) activation, and are morphologically distinct from flat extended lamellipodia [5].
  • The c-Met mRNA was expressed in a variety of canine tissues including peripheral blood mononuclear cells (PBMC), bone marrow, liver, kidney, lung, stomach, uterus, testis, thymus, lymph node, small intestine, colon, adrenal gland, thyroid gland, heart, muscle, skin, pancreas, ovary, prostate, spleen, fat, cerebrum, and cerebellum [3].
  • We have found here a novel signaling pathway of c-Met consisting of SHP-2-Rho that regulates the assembly and disassembly of stress fibers and focal adhesions in MDCK cells [6].
  • In these cell lines, the HGF- or TPA-induced coendocytosis of E-cadherin and c-Met was inhibited, but the coendocytosis of E-cadherin and c-Met in response to reduction of medium Ca2+ was not affected [4].
 

Associations of MET with chemical compounds

 

Other interactions of MET

  • CONCLUSIONS: The localized activation of an autocrine HGF/c-Met loop regulates Rho/ROCK activation of p38 MAPK signalling to stimulate both membrane blebbing and pseudopod formation [5].
 

Analytical, diagnostic and therapeutic context of MET

References

  1. A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis. Hartmann, G., Naldini, L., Weidner, K.M., Sachs, M., Vigna, E., Comoglio, P.M., Birchmeier, W. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Src homology 2-containing inositol 5-phosphatase 1 binds to the multifunctional docking site of c-Met and potentiates hepatocyte growth factor-induced branching tubulogenesis. Stefan, M., Koch, A., Mancini, A., Mohr, A., Weidner, K.M., Niemann, H., Tamura, T. J. Biol. Chem. (2001) [Pubmed]
  3. Molecular cloning of the canine c-Met/HGF receptor and its expression in normal and regenerated liver. Neo, S., Kansaku, N., Furuichi, M., Watanabe, M., Hisamatsu, S., Ohno, K., Hisasue, M., Tsuchiya, R., Yamada, T. J. Vet. Med. Sci. (2005) [Pubmed]
  4. Coendocytosis of cadherin and c-Met coupled to disruption of cell-cell adhesion in MDCK cells--regulation by Rho, Rac and Rab small G proteins. Kamei, T., Matozaki, T., Sakisaka, T., Kodama, A., Yokoyama, S., Peng, Y.F., Nakano, K., Takaishi, K., Takai, Y. Oncogene (1999) [Pubmed]
  5. Rho/ROCK-dependent pseudopodial protrusion and cellular blebbing are regulated by p38 MAPK in tumour cells exhibiting autocrine c-Met activation. Jia, Z., Vadnais, J., Lu, M.L., Noël, J., Nabi, I.R. Biol. Cell (2006) [Pubmed]
  6. Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering. Kodama, A., Matozaki, T., Fukuhara, A., Kikyo, M., Ichihashi, M., Takai, Y. Mol. Biol. Cell (2000) [Pubmed]
  7. Cytosolic phospholipase A2 is activated by the hepatocyte growth factor receptor-kinase in Madin Darby canine kidney cells. Skouteris, G.G., Schröder, C.H. J. Cell. Sci. (1997) [Pubmed]
 
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