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CTLA4  -  cytotoxic T-lymphocyte-associated protein 4

Canis lupus familiaris

 
 
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Disease relevance of CTLA4

  • For therapeutic gene construction, the extracellular domain of canine CTLA-4, and the CH2-CH3 domains of canine immunoglobulin alpha constant region were inserted between the cytomegalovirus promoter and poly-adenylation sequence of bovine growth hormone [1].
  • The autoantibodies against CTLA-4, demonstrated here for the first time in canine autoimmune diseases, may modulate the immune response in dogs with autoimmune diseases [2].
 

High impact information on CTLA4

  • For the therapeutic purpose of allergic diseases in dogs, a DNA construct which expresses recombinant fusion protein with two functional domains, cytotoxic T lymphocyte antigen (CTLA-4) and Fcepsilon receptor Ialpha, was developed to bridge antigen-presenting cells and IgE-allergen complex [3].
  • CTLA-4 recombinant protein genetically fused to canine Fcepsilon receptor Ialpha enhances allergen specific lymphocyte responses in experimentally sensitized dogs [3].
  • Expression of CD28, CTLA-4 and CD86 were suppressed following CPAg-stimulation [4].
  • In this study, we prepared recombinant proteins of CTLA-4 (CD152) and CD28 and investigated the presence of autoantibodies against them in serum samples obtained from dogs with various autoimmune diseases and from healthy dogs as controls, using the recombinant GST fusion proteins by ELISA [2].

References

  1. Gene therapy using non-viral peptide vector in a canine systemic lupus erythematosus model. Choi, E.W., Shin, I.S., Youn, H.Y., Kim, D.Y., Lee, H., Chae, Y.J., Lee, C.W. Vet. Immunol. Immunopathol. (2005) [Pubmed]
  2. Autoantibodies against T-Cell costimulatory molecules are produced in canine autoimmune diseases. Khatlani, T.S., Ma, Z., Okuda, M., Inokuma, H., Onishi, T. J. Immunother. (2003) [Pubmed]
  3. CTLA-4 recombinant protein genetically fused to canine Fcepsilon receptor Ialpha enhances allergen specific lymphocyte responses in experimentally sensitized dogs. Yasunaga, S., Tsukui, T., Masuda, K., Ohno, K., Tsujimoto, H. J. Vet. Med. Sci. (2004) [Pubmed]
  4. Antigen-specific enhancements of CD80 mRNA expression in experimentally sensitized dogs with Japanese cedar pollen. Yasunaga, S., Masuda, K., Ohno, K., Tsujimoto, H. J. Vet. Med. Sci. (2003) [Pubmed]
 
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