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Gene Review:

TRDN - triadin

Canis lupus familiaris

Kobayashi, Y.M. et al., Györke, I. et al.

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High impact information on TRDN

Identification of triadin 1 as the predominant triadin isoform expressed in mammalian myocardium [1].
CSQ apparently serves as a luminal Ca sensor that inhibits the channel at low luminal [Ca], whereas triadin 1 and/or junctin may be required to mediate interactions of CSQ with RyR [2].

Anatomical context of TRDN

Several triadin isoforms have been postulated to exist in cardiac muscle, but to date none has been conclusively identified [1].

Associations of TRDN with chemical compounds

In RyRs reassociated with triadin 1 and junctin, adding luminal CSQ produced a significant decrease in activity [2].

References

Identification of triadin 1 as the predominant triadin isoform expressed in mammalian myocardium. Kobayashi, Y.M., Jones, L.R. J. Biol. Chem. (1999) [Pubmed]
The role of calsequestrin, triadin, and junctin in conferring cardiac ryanodine receptor responsiveness to luminal calcium. Györke, I., Hester, N., Jones, L.R., Györke, S. Biophys. J. (2004) [Pubmed]

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TRDN	Bos taurus
TRDN	Homo sapiens
TRDN	Macaca mulatta
Trdn	Mus musculus
Trdn	Rattus norvegicus

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