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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IL5  -  interleukin 5 (colony-stimulating factor,...

Canis lupus familiaris

 
 
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High impact information on IL5

  • The activation of eosinophils by IL-5 plays a crucial role in the pathogenesis of allergic and parasitic disorders [1].
  • IL-5 has recently been shown to activate Lyn and Jak2 tyrosine kinases, MAP kinases, and STAT1 nuclear factor [1].
  • There was significantly different amount of mRNA encoding IL-5, IL-18 and TNF-alpha between particular anatomical levels of the respiratory mucosa while the mRNA expression of the other cytokines was similar at all anatomical sites [2].
  • The effects of salivary gland extract (SGE) from R. sanguineus were examined on the production of IgG1 and IgG2 and the mRNA expression of IFN-gamma, IL-2, IL-4, IL-5 and IL-10 in the mononuclear cells from canine peripheral blood, treated with concanavalin A (ConA) in vitro [3].
 

Analytical, diagnostic and therapeutic context of IL5

  • Taken together, these results suggest that the Th2-like response in PBMCs from dogs with demodicosis is up-regulated, and that subsequent increased expression of IL-5 and TGF-beta mRNA in dogs with GD is reversible after treatment [4].

References

  1. Mechanism of inhibition of eosinophil activation by transforming growth factor-beta. Inhibition of Lyn, MAP, Jak2 kinases and STAT1 nuclear factor. Pazdrak, K., Justement, L., Alam, R. J. Immunol. (1995) [Pubmed]
  2. Real-time RT-PCR quantification of mRNA encoding cytokines and chemokines in histologically normal canine nasal, bronchial and pulmonary tissue. Peeters, D., Peters, I.R., Farnir, F., Clercx, C., Day, M.J. Vet. Immunol. Immunopathol. (2005) [Pubmed]
  3. Effects of salivary gland extract from Rhipicephalus sanguineus on IgG subclass production and cytokine mRNA expression in mononuclear cells of canine peripheral blood. Matsumoto, K., Inokuma, H., Okuda, M., Onishi, T. J. Vet. Med. Sci. (2003) [Pubmed]
  4. Evaluation of cytokine messenger RNA expression in peripheral blood mononuclear cells from dogs with canine demodicosis. Tani, K., Morimoto, M., Hayashi, T., Inokuma, H., Ohnishi, T., Hayashiya, S., Nomura, T., Une, S., Nakaichi, M., Taura, Y. J. Vet. Med. Sci. (2002) [Pubmed]
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