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Gene Review

Rpn10  -  Regulatory particle non-ATPase 10

Drosophila melanogaster

Synonyms: 26S proteasome non-ATPase regulatory subunit 4, 26S proteasome regulatory subunit RPN10, 26S proteasome regulatory subunit S5A, 54 kDa subunit of mu particle, 7619, ...
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High impact information on Pros54

  • Deletion of the subunit S5a/Rpn10/p54 does not destabilise the regulatory complex and does not disturb the assembly of the regulatory complex and the catalytic core [1].
  • The expression and phosphorylation of the p54 USP is regulated by 20E [2].

Analytical, diagnostic and therapeutic context of Pros54

  • Western blot analysis revealed four USP mAb reactive bands (p46, p48, p54 and p56), each with tissue- and stage-specific expression patterns [2].


  1. Deletion of proteasomal subunit S5a/Rpn10/p54 causes lethality, multiple mitotic defects and overexpression of proteasomal genes in Drosophila melanogaster. Szlanka, T., Haracska, L., Kiss, I., Deák, P., Kurucz, E., Andó, I., Virágh, E., Udvardy, A. J. Cell. Sci. (2003) [Pubmed]
  2. 20E-regulated USP expression and phosphorylation in Drosophila melanogaster. Song, Q., Sun, X., Jin, X.Y. Insect Biochem. Mol. Biol. (2003) [Pubmed]
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