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Disease relevance of MUCIN

 

Psychiatry related information on MUCIN

 

High impact information on MUCIN

  • The specificity of the cross-reactivities was confirmed by testing the binding of the reactive anti-TEPC-15 MAb to both CRP and limulin in the presence of p-nitrophenylphosphorylcholine (pNPPC), N-acetylneuraminic acid, and bovine submaxillary mucin [7].
  • Bovine submaxillary mucin and chicken ovoinhibitor can also prevent the shedding of rotavirus antigen and the development of rotavirus gastroenteritis in a mouse model of rotavirus infection [2].
  • Bovine gallbladder mucin accelerates cholesterol monohydrate crystal growth in model bile [3].
  • Mean hydrogen production from substrates containing less than 3% sugar (human serum albumin, bovine serum albumin, and alpha-casein) averaged 2.2 +/- 0.9% of hydrogen production from equivalent amounts of glucose, while carbohydrate-rich mucin yielded 46.0 +/- 6.7% of hydrogen production from glucose [8].
  • N-Acetylglucosamine at a concentration of 20 mmol/L almost completely inhibited WGA-induced CL production by neutrophils, whereas bovine submaxillary gland mucin, a potent blocker of NANA binding of WGA, failed to inhibit CL production [9].
 

Chemical compound and disease context of MUCIN

 

Biological context of MUCIN

 

Anatomical context of MUCIN

  • When dietary CP rose from 1 to 28%, the flow of mucin protein increased at the duodenum (+300%) [15].
  • The objective of this study was to investigate the effect of the dietary crude protein (CP) content and origin on the flow of mucin protein along the small intestine of the preruminant calf [15].
  • In experiment 2, the flow of mucin protein increased by 70% at the duodenum and at the jejunum when SMP was partially replaced by SPC and HSPI [15].
  • Bovine gallbladder mucin (0.5-8 mg/mL) accelerated crystal growth in supersaturated model bile in a concentration- and time-dependent fashion compared with control incubations with bovine serum albumin or model bile alone (P < 0.05) [3].
  • One such mucin is found in human milk fat globule membrane and consists predominantly of O-linked sugars and a protein core [16].
 

Associations of MUCIN with chemical compounds

 

Regulatory relationships of MUCIN

  • AIM: To determine the thermodynamics of binding reaction of arginine oligomer (R8) to bovine submaxillary mucin (BSM) in order to provide the foundation for understanding the influence of mucin on transport of macromolecules through mucosa mediated by arginine oligomer [19].
 

Other interactions of MUCIN

  • The role of sialic acid in the gel-filtration behaviour of sialoglycoproteins was investigated by using the separated isoenzymes of purified human liver alpha-L-fucosidase and several other well-known sialic acid-containing glycoproteins (fetuin, alpha1-acid glycoprotein, thyroglobulin and bovine submaxillary mucin) [20].
  • Adherence was saturable, time and dose dependent, and selectively blocked by glycoconjugates, in particular bovine submaxillary mucin, fetuin, and asialofetuin, suggesting that it may be mediated by a lectin type of interaction [21].
  • The enzyme liberated the sialic acid residues from (alpha 2-3) and (alpha 2-6) sialyllactose, colomic acid, fetuin, and transferrin, but not from bovine submaxillary mucin [22].
 

Analytical, diagnostic and therapeutic context of MUCIN

References

  1. Isolation and characterization of peptides from the protein core of bovine gallbladder mucin. Afdhal, N.H., Offner, G.D., Murray, F.E., Troxler, R.F., Smith, B.F. Gastroenterology (1990) [Pubmed]
  2. Sialic acid glycoproteins inhibit in vitro and in vivo replication of rotaviruses. Yolken, R.H., Willoughby, R., Wee, S.B., Miskuff, R., Vonderfecht, S. J. Clin. Invest. (1987) [Pubmed]
  3. Bovine gallbladder mucin accelerates cholesterol monohydrate crystal growth in model bile. Afdhal, N.H., Niu, N., Gantz, D., Small, D.M., Smith, B.F. Gastroenterology (1993) [Pubmed]
  4. Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosamine transferase from an ascites hepatoma, AH 66. Sugiura, M., Kawasaki, T., Yamashina, I. J. Biol. Chem. (1982) [Pubmed]
  5. A new endo-beta-galactosidase releasing Gal alpha 1----3Gal from carbohydrate moieties of glycoproteins and from a glycolipid. Fushuku, N., Muramatsu, H., Uezono, M.M., Muramatsu, T. J. Biol. Chem. (1987) [Pubmed]
  6. Effects of bovine alpha-lactalbumin on gastric defense mechanisms in naive rats. Ushida, Y., Shimokawa, Y., Matsumoto, H., Toida, T., Hayasawa, H. Biosci. Biotechnol. Biochem. (2003) [Pubmed]
  7. Invertebrate recognition protein cross-reacts with an immunoglobulin idiotype. Vasta, G.R., Marchalonis, J.J., Kohler, H. J. Exp. Med. (1984) [Pubmed]
  8. Glycoproteins as substrates for production of hydrogen and methane by colonic bacterial flora. Perman, J.A., Modler, S. Gastroenterology (1982) [Pubmed]
  9. Mechanism of neutrophil chemiluminescence induced by wheat germ agglutinin: partial characterization of the antigens recognized by wheat germ agglutinin. Ozaki, Y., Iwata, J., Ohashi, T. Blood (1984) [Pubmed]
  10. Bacterial adsorption to fetuin and mucin pellicle. Hirano, Y., Tamura, M., Sekine, Y., Nemoto, Y., Hayashi, K. The Journal of Nihon University School of Dentistry. (1995) [Pubmed]
  11. Possible mechanism of inhibition of experimental pulmonary metastasis of mouse colon adenocarcinoma 26 sublines by a sialic acid: nucleoside conjugate. Kijima-Suda, I., Miyazawa, T., Itoh, M., Toyoshima, S., Osawa, T. Cancer Res. (1988) [Pubmed]
  12. Study of the primary structures of the peptide core of bovine estrus cervical mucin. Possible existence of small similar subunits. Rao, K.S., Masson, P.L. J. Biol. Chem. (1977) [Pubmed]
  13. Stable thiobarbituric acid chromophore with dimethyl sulphoxide. Application to sialic acid assay in analytical de-O-acetylation. Skoza, L., Mohos, S. Biochem. J. (1976) [Pubmed]
  14. Expression of mucin synthesis and secretion in human tracheobronchial epithelial cells grown in culture. Wu, R., Martin, W.R., Robinson, C.B., St George, J.A., Plopper, C.G., Kurland, G., Last, J.A., Cross, C.E., McDonald, R.J., Boucher, R. Am. J. Respir. Cell Mol. Biol. (1990) [Pubmed]
  15. Influence of dietary protein level and origin on the flow of mucin along the small intestine of the preruminant calf. Montagne, L., Toullec, R., Formal, M., Lallès, J.P. J. Dairy Sci. (2000) [Pubmed]
  16. Synthetic peptides reactive with anti-human milk fat globule membrane monoclonal antibodies. Xing, P.X., Reynolds, K., Tjandra, J.J., Tang, X.L., McKenzie, I.F. Cancer Res. (1990) [Pubmed]
  17. Purification and properties of a Ca2+-independent sialic acid-binding lectin from human placenta with preferential affinity to O-acetylsialic acids. Ahmed, H., Gabius, H.J. J. Biol. Chem. (1989) [Pubmed]
  18. Identification of the mucin core protein by cell-free translation of messenger RNA from bovine submaxillary glands. Bhavanandan, V.P., Hegarty, J.D. J. Biol. Chem. (1987) [Pubmed]
  19. Interaction of a novel peptoid enhancer--arginine oligomer with bovine submaxillary mucin. Liang, W., Davalian, D., Torchilin, V.P. Yao Xue Xue Bao (2004) [Pubmed]
  20. Gel filtration of sialoglycoproteins. Alhadeff, J.A. Biochem. J. (1978) [Pubmed]
  21. A novel in situ model to study Pneumocystis carinii adhesion to lung alveolar epithelial cells. Pavia-Ruz, N., Ortega-Barria, E., Alroy, J., Pereira, M.E. J. Immunol. Methods (1994) [Pubmed]
  22. Human placental sialidase: partial purification and characterization. Hiraiwa, M., Uda, Y., Nishizawa, M., Miyatake, T. J. Biochem. (1987) [Pubmed]
  23. Novel carbohydrate-binding activity of pancreatic trypsins to N-linked glycans of glycoproteins. Takekawa, H., Ina, C., Sato, R., Toma, K., Ogawa, H. J. Biol. Chem. (2006) [Pubmed]
  24. Mucin biosynthesis: molecular cloning and expression of bovine lung mucin core 2 N-acetylglucosaminyltransferase cDNA. Li, C.M., Adler, K.B., Cheng, P.W. Am. J. Respir. Cell Mol. Biol. (1998) [Pubmed]
  25. pH-dependent mucoadhesion of a poly(N-isopropylacrylamide) copolymer reveals design rules for drug delivery. Zhu, X., Degraaf, J., Winnik, F.M., Leckband, D. Langmuir : the ACS journal of surfaces and colloids. (2004) [Pubmed]
  26. Silver staining of extensively glycosylated proteins on sodium dodecyl sulfate-polyacrylamide gels: enhancement by carbohydrate-binding dyes. Jay, G.D., Culp, D.J., Jahnke, M.R. Anal. Biochem. (1990) [Pubmed]
 
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