Gene Review:
GNLY - granulysin
Bos taurus
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Disease relevance of GNLY
- Synthetic human, bovine, and swine peptides corresponding to the C terminus of helix 2 through helix 3 region of granulysin displayed potent antimicrobial activity against Escherichia coli, Salmonella enteritidis, Staphylococcus aureus, and Mycobacterium bovis bacillus Calmette-Guérin [1].
- A murine counterpart to granulysin has not been identified to date, indicating the importance of additional models to fully characterize the role of granulysin-like molecules in the immune response to infectious disease [1].
High impact information on GNLY
- Intracellular flow cytometry and immunoblotting confirmed the presence of protein corresponding to the bovine granulysin homologue in activated T lymphocytes and PBMC [1].
References
- Characterization of bovine homologues of granulysin and NK-lysin. Endsley, J.J., Furrer, J.L., Endsley, M.A., McIntosh, M.A., Maue, A.C., Waters, W.R., Lee, D.R., Estes, D.M. J. Immunol. (2004) [Pubmed]
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