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Gene Review:

SLEB4 - systemic lupus erythematosus,...

Homo sapiens

Nath, S.K. et al., Elliott, J.I. et al.

Nath, Quintero-Del-Rio, Kilpatrick, Feo, Ballesteros, Harley, Elliott, McVey, Higgins,

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Disease relevance of SLEB4

Therefore, our results have detected, established, and confirmed the existence of a novel SLE susceptibility locus at 12q24 (designated "SLEB4") that may cause lupus, especially in Hispanic and European American families [1].

High impact information on SLEB4

We show that current mapping suggests that murine and human P2RX7 receptor genes lie within lupus susceptibility loci lbw3 and SLEB4, and we argue that these encode a product with the functional characteristics consistent with a role in lupus [2].

References

Linkage at 12q24 with systemic lupus erythematosus (SLE) is established and confirmed in Hispanic and European American families. Nath, S.K., Quintero-Del-Rio, A.I., Kilpatrick, J., Feo, L., Ballesteros, M., Harley, J.B. Am. J. Hum. Genet. (2004) [Pubmed]
The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products. Elliott, J.I., McVey, J.H., Higgins, C.F. Arthritis Res. Ther. (2005) [Pubmed]

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