The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

myh4  -  myosin, heavy chain 4, skeletal muscle

Xenopus (Silurana) tropicalis

Synonyms: E3, mhc, myh2b, myhc-2b, myhc-iib, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on MGC75596

  • A Xenopus nonmuscle myosin heavy chain isoform is phosphorylated by cyclin-p34cdc2 kinase during meiosis [1].
  • Hybrid fibre types containing two MHC isoforms exhibited stretch activation kinetics parameters that were intermediate between those of the corresponding pure fibre types [2].
  • These results clearly show that the MHC isoforms expressed in Xenopus muscle are functionally different thereby validating the idea that MHC isoform composition is the most reliable criterion for vertebrate skeletal muscle fibre type classification [2].
  • In the nonmuscle MHC, the insert in this region is a different size and sequence of amino acids than that in the smooth muscle MHC [3].
  • The particular isoforms discussed are those that are generated by alternative splicing near the 5' end of the pre-mRNA, resulting in either an insertion or a deletion of a cassette of amino acids near the amino-terminus of the myosin heavy chain (MHC) protein [3].
 

Analytical, diagnostic and therapeutic context of MGC75596

  • Using a SDS-PAGE protocol that proved successful with mammalian muscle MHC isoforms, we were able to detect five MHC isoforms in Xenopus iliofibularis muscle [2].

References

  1. A Xenopus nonmuscle myosin heavy chain isoform is phosphorylated by cyclin-p34cdc2 kinase during meiosis. Kelley, C.A., Oberman, F., Yisraeli, J.K., Adelstein, R.S. J. Biol. Chem. (1995) [Pubmed]
  2. Myosin heavy chain isoform composition and stretch activation kinetics in single fibres of Xenopus laevis iliofibularis muscle. Andruchova, O., Stephenson, G.M., Andruchov, O., Stephenson, D.G., Galler, S. J. Physiol. (Lond.) (2006) [Pubmed]
  3. Characterization of isoform diversity among smooth muscle and nonmuscle myosin heavy chains. Kelley, C.A. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1997) [Pubmed]
 
WikiGenes - Universities