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Gene Review

myh4  -  myosin, heavy chain 4, skeletal muscle

Xenopus (Silurana) tropicalis

Synonyms: E3, mhc, myh2b, myhc-2b, myhc-iib, ...
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High impact information on MGC75596

  • A Xenopus nonmuscle myosin heavy chain isoform is phosphorylated by cyclin-p34cdc2 kinase during meiosis [1].
  • Hybrid fibre types containing two MHC isoforms exhibited stretch activation kinetics parameters that were intermediate between those of the corresponding pure fibre types [2].
  • These results clearly show that the MHC isoforms expressed in Xenopus muscle are functionally different thereby validating the idea that MHC isoform composition is the most reliable criterion for vertebrate skeletal muscle fibre type classification [2].
  • In the nonmuscle MHC, the insert in this region is a different size and sequence of amino acids than that in the smooth muscle MHC [3].
  • The particular isoforms discussed are those that are generated by alternative splicing near the 5' end of the pre-mRNA, resulting in either an insertion or a deletion of a cassette of amino acids near the amino-terminus of the myosin heavy chain (MHC) protein [3].

Analytical, diagnostic and therapeutic context of MGC75596

  • Using a SDS-PAGE protocol that proved successful with mammalian muscle MHC isoforms, we were able to detect five MHC isoforms in Xenopus iliofibularis muscle [2].


  1. A Xenopus nonmuscle myosin heavy chain isoform is phosphorylated by cyclin-p34cdc2 kinase during meiosis. Kelley, C.A., Oberman, F., Yisraeli, J.K., Adelstein, R.S. J. Biol. Chem. (1995) [Pubmed]
  2. Myosin heavy chain isoform composition and stretch activation kinetics in single fibres of Xenopus laevis iliofibularis muscle. Andruchova, O., Stephenson, G.M., Andruchov, O., Stephenson, D.G., Galler, S. J. Physiol. (Lond.) (2006) [Pubmed]
  3. Characterization of isoform diversity among smooth muscle and nonmuscle myosin heavy chains. Kelley, C.A. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1997) [Pubmed]
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