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Gene Review:

Alh - Alhambra

Drosophila melanogaster

Synonyms: AF10, CG1070, Dalf, Dmel\CG1070, anon-WO0118547.226, ...

Bahri, S.M. et al., Linder, B. et al., Perrin, L. et al., Perrin, L. et al.

Perrin, Bloyer, Ferraz, Agrawal, Sinha, Dura,

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High impact information on Alh

This deregulation is conserved in the human AF10 leucine zipper domain, which confers the same activity on an oncogenic MLL-AF10 fusion protein expressed in Drosophila melanogaster [1].
In chromosomal rearrangements of acute myeloid leukaemia patients the mixed lineage leukaemia (MLL) gene, a human homolog of the Drosophila gene trithorax, is frequently fused to AF10 [2].
Like its human counterparts, Dalf encodes a zinc finger/leucine zipper nuclear protein that is widely expressed in embryonic and larval tissues including neurons and glia [3].
This indicates a requirement for Dalf function in the nervous system for maintaining gene expression and the facilitation of normal growth [3].
In addition to the embryonic phenotype, Dalf mutant larvae are retarded in their growth and this defect can be rescued by the ectopic expression of a Dalf transgene under the control of a neuronal GAL4 driver [3].

Biological context of Alh

Molecular genetics of the Alhambra (Drosophila AF10) complex locus of Drosophila [4].

References

The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions. Perrin, L., Bloyer, S., Ferraz, C., Agrawal, N., Sinha, P., Dura, J.M. Mol. Cell. Biol. (2003) [Pubmed]
The Drosophila homolog of the human AF10 is an HP1-interacting suppressor of position effect variegation. Linder, B., Gerlach, N., Jäckle, H. EMBO Rep. (2001) [Pubmed]
The Drosophila homolog of human AF10/AF17 leukemia fusion genes (Dalf) encodes a zinc finger/leucine zipper nuclear protein required in the nervous system for maintaining EVE expression and normal growth. Bahri, S.M., Chia, W., Yang, X. Mech. Dev. (2001) [Pubmed]
Molecular genetics of the Alhambra (Drosophila AF10) complex locus of Drosophila. Perrin, L., Dura, J.M. Mol. Genet. Genomics (2004) [Pubmed]

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