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Gene Review:

Ubc84D - Ubiquitin conjugating enzyme 84D

Drosophila melanogaster

Synonyms: CG12799, Dmel\CG12799, Ubiquitin carrier protein, Ubiquitin-conjugating enzyme E2-18 kDa, Ubiquitin-protein ligase, ...

Greene, J.C. et al., Máthé, E. et al.

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Disease relevance of Ubc84D

Loss-of-function mutations of the parkin gene, which encodes a ubiquitin-protein ligase, are a common cause of autosomal recessive juvenile parkinsonism (ARJP) [1].

High impact information on Ubc84D

This is regulated at the level of conjugation of ubiquitin to substrates by the anaphase-promoting complex/cyclosome (APC/C) ubiquitin-protein ligase [2].

References

Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis. Greene, J.C., Whitworth, A.J., Andrews, L.A., Parker, T.J., Pallanck, L.J. Hum. Mol. Genet. (2005) [Pubmed]
The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation. Máthé, E., Kraft, C., Giet, R., Deák, P., Peters, J.M., Glover, D.M. Curr. Biol. (2004) [Pubmed]

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