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Gene Review

Prat  -  Phosphoribosylamidotransferase

Drosophila melanogaster

Synonyms: ATase, Amidophosphoribosyltransferase, CG2867, DmPrat, Dmel\CG2867, ...
 
 
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Disease relevance of Prat

  • Using the GAL4-UAS system, Prat RNAi driven by Act5c-GAL4 or tubP-GAL4 causes variable pupal lethality (48-100%) and approximately 50% female sterility, depending on the transgenic strains and drivers used [1].
 

High impact information on Prat

  • We conclude that Prat2 is required during the prepupal stage while Prat is more important for the pupal stage [1].
  • This observation agrees with the phenotype previously observed for Prat EMS-induced mutations [1].
  • PRAT (phosphoribosylamidotransferase; E.C. 2.4.2.14) catalyzes the first reaction in de novo purine nucleotide biosynthesis [1].
  • To study the regulation of Prat expression in the adult eye, we used the Prat:bw reporter gene, in which the Prat coding region was replaced with the brown (bw) coding region [2].
  • Quantification of their effect on endogenous Prat gene expression, using RT-PCR in young adult fly heads, identifies a subset of modifiers that are candidates for genes involved in regulating Prat expression [2].
 

Biological context of Prat

 

Associations of Prat with chemical compounds

References

 
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