High impact information on Art4

• We demonstrate that CARMER associates with the ecdysone receptor complex and modulates the ecdysone-induced transcription of a number of apoptotic genes [1].
• Ablation of CARMER blocks ecdysone-induced cell death in Drosophila cells, but not apoptosis induced by cell stress [1].
• An arginine-histone methyltransferase, CARMER, coordinates ecdysone-mediated apoptosis in Drosophila cells [1].
• DART1 and DART4 have arginine methyltransferase activity towards substrates, including histones and RNA-binding proteins [2].

Biological context of Art4

• Here we show that CARMER, an arginine-histone methyltransferase, is critical in coordinating ecdysone-induced expression of Drosophila cell death genes [1].

Associations of Art4 with chemical compounds

• Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4 [2].

References