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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Bruce  -  CG6303 gene product from transcript CG6303-RD

Drosophila melanogaster

Synonyms: BRUCE, CG6303, Dmel\CG6303, bruce, dBRUCE, ...
 
 
 
 
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High impact information on Bruce

  • Drosophila Bruce can potently suppress Rpr- and Grim-dependent but not Hid-dependent cell death [1].
  • However, it is still unknown whether Bruce inhibits apoptosis directly or instead plays some other more indirect role in mediating chemoresistance, perhaps by promoting drug export, decreasing the efficacy of DNA damage-dependent cell death signaling, or by promoting DNA repair [1].
  • BRUCE upregulation occurs in some cancers and contributes to the resistance of these cells to DNA-damaging chemotherapeutic drugs [1].

References

  1. Drosophila Bruce can potently suppress Rpr- and Grim-dependent but not Hid-dependent cell death. Vernooy, S.Y., Chow, V., Su, J., Verbrugghe, K., Yang, J., Cole, S., Olson, M.R., Hay, B.A. Curr. Biol. (2002) [Pubmed]
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