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Gene Review:

HisCl1 - Histamine-gated chloride channel subunit 1

Drosophila melanogaster

Synonyms: CG14723, CT34515, DMHisClalpha2, Dm-HCLB, DmHisCl1, ...

Zheng, Y. et al., Gisselmann, G. et al.

Gisselmann, Pusch, Hovemann, Hatt,

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High impact information on HisCl1

By systematic expression screening of novel putative ligand-gated anion channels, we identified two cDNAs (DM-HisCl-alpha 1 and-alpha 2) coding for putative histamine-gated chloride channels by functional expression in Xenopus laevis oocytes [1].
The encoded proteins, HisCl1 and HisCl2, share 60% amino acid identity with each other [2].
Co-injection of both hisCl1 and hisCl2 RNAs resulted in expression of a histamine-gated chloride channel with increased sensitivity to histamine, demonstrating coassembly of the subunits [2].

Anatomical context of HisCl1

Oocytes injected with in vitro transcribed RNA, encoding either HisCl1 or HisCl2, produced substantial chloride currents in response to histamine but not in response to GABA, glycine, and glutamate [2].

References

Two cDNAs coding for histamine-gated ion channels in D. melanogaster. Gisselmann, G., Pusch, H., Hovemann, B.T., Hatt, H. Nat. Neurosci. (2002) [Pubmed]
Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye. Zheng, Y., Hirschberg, B., Yuan, J., Wang, A.P., Hunt, D.C., Ludmerer, S.W., Schmatz, D.M., Cully, D.F. J. Biol. Chem. (2002) [Pubmed]

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