Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

ASS1 - argininosuccinate synthase 1

Sus scrofa

Rosebrough, R.W. et al., Su, Y. et al., Su, Y. et al., Soler, G. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ASS1

Hypoxia inhibits the induction of argininosuccinate synthetase by endotoxin in lung endothelial cells [1].

High impact information on ASS1

The conversion of L-citrulline to L-argininosuccinate by argininosuccinate synthetase (AS) was inhibited by exposure to hypoxia for 4, 12, or 24 h [2].
The activities of arginase, argininosuccinate synthetase and argininosuccinate lyase were increased in a linear fashion by increasing the dietary protein level [3].
After slaughter, urea cycle enzyme activities (argininosuccinate synthetase, EC 6.3.4.5; argininosuccinate lyase, EC 4.3.2.1; and arginase, EC 3.5.3.1) were determined in liver homogenates [3].
Arginine as competitive inhibitor of argininosuccinate synthetase from guinea pig liver [4].

References

Hypoxia inhibits the induction of argininosuccinate synthetase by endotoxin in lung endothelial cells. Su, Y., Block, E.R. Am. J. Physiol. (1997) [Pubmed]
Hypoxia inhibits L-arginine synthesis from L-citrulline in porcine pulmonary artery endothelial cells. Su, Y., Block, E.R. Am. J. Physiol. (1995) [Pubmed]
Effect of protein level and supplemental lysine on growth and urea cycle enzyme activity in the pig. Rosebrough, R.W., Steele, N.C., McMurtry, J.P. Growth. (1983) [Pubmed]
Arginine as competitive inhibitor of argininosuccinate synthetase from guinea pig liver. Soler, G., Mataix, F.J., Ruiz-Amil, M. Rev. Esp. Fisiol. (1981) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.