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TGFA  -  transforming growth factor, alpha

Gallus gallus

 
 
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High impact information on TGFA

 

Biological context of TGFA

 

Anatomical context of TGFA

 

Associations of TGFA with chemical compounds

 

Regulatory relationships of TGFA

 

Other interactions of TGFA

 

Analytical, diagnostic and therapeutic context of TGFA

  • By Western blotting techniques, we identified a protein complex composed of a least two TGF-alpha immunoreactive subunits of 40 and 88 kDa, respectively [9].
  • TGF beta (2-100 ng/ml) stimulated PAc activity in a dose-dependent manner only in cultures of granulosa cells from F5-6 follicles and significantly enhanced TGF alpha-induced PAc and PAm activities in cell cultures from F3 and F5-6, but not F1, follicles [8].
  • Immunocytochemistry revealed that EGF, but not TGFalpha, was present in the germinal disc of the four largest preovulatory follicles of the hen [10].

References

  1. A hepatitis B virus pre-S-retinoic acid receptor beta chimera transforms erythrocytic progenitor cells in vitro. Garcia, M., de Thé, H., Tiollais, P., Samarut, J., Dejean, A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. An alternatively processed mRNA from the avian c-erbB gene encodes a soluble, truncated form of the receptor that can block ligand-dependent transformation. Flickinger, T.W., Maihle, N.J., Kung, H.J. Mol. Cell. Biol. (1992) [Pubmed]
  3. The significance of valine 33 as a ligand-specific epitope of transforming growth factor alpha. Puddicombe, S.M., Chamberlin, S.G., MacGarvie, J., Richter, A., Drummond, D.R., Collins, J., Wood, L., Davies, D.E. J. Biol. Chem. (1996) [Pubmed]
  4. Roles of transforming growth factor-alpha and epidermal growth factor in chick limb development. Dealy, C.N., Scranton, V., Cheng, H.C. Dev. Biol. (1998) [Pubmed]
  5. Susceptibility of avian ovarian granulosa cells to apoptosis is dependent upon stage of follicle development and is related to endogenous levels of bcl-xlong gene expression. Johnson, A.L., Bridgham, J.T., Witty, J.P., Tilly, J.L. Endocrinology (1996) [Pubmed]
  6. Follicular stage-dependent tumor necrosis factor alpha-induced hen granulosa cell integrin production and survival in the presence of transforming growth factor alpha in vitro. Soboloff, J., Sasaki, H., Tsang, B.K. Biol. Reprod. (2001) [Pubmed]
  7. Up-regulation of urokinase plasminogen activator messenger ribonucleic acid and protein in hen granulosa cells by transforming growth factor alpha in vitro during follicular development. Li, J., Croze, F., Yan, W., Haché, R.J., Tsang, B.K. Biol. Reprod. (1997) [Pubmed]
  8. Interactions of transforming growth factor-alpha and -beta and luteinizing hormone in the regulation of plasminogen activator activity in avian granulosa cells during follicular development. Lafrance, M., Zhou, L., Tsang, B.K. Endocrinology (1993) [Pubmed]
  9. Immunochemical study of a transforming growth factor-alpha-related protein in the chicken kidney. Díaz-Ruiz, C., Asbert, M., Pérez-Tomás, R. Kidney Int. (1996) [Pubmed]
  10. Epidermal growth factor in the germinal disc and its potential role in follicular development in the chicken. Volentine, K.K., Yao, H.H., Bahr, J.M. Biol. Reprod. (1998) [Pubmed]
  11. Induction of cell proliferation in avian inner ear sensory epithelia by insulin-like growth factor-I and insulin. Oesterle, E.C., Tsue, T.T., Rubel, E.W. J. Comp. Neurol. (1997) [Pubmed]
  12. Bcl-X(LONG) protein expression and phosphorylation in granulosa cells. Johnson, A.L., Bridgham, J.T., Jensen, T. Endocrinology (1999) [Pubmed]
  13. Differentiation of chick lens epithelial cells: involvement of the epidermal growth factor receptor and endogenous ligand. Ireland, M.E., Mrock, L.K. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  14. Effects of transforming growth factor-alpha on chicken adipocyte precursor cells in vitro. Butterwith, S.C., Peddie, C.D., Goddard, C. J. Endocrinol. (1992) [Pubmed]
  15. Effects of insulin-like growth factor I and interactions with transforming growth factor alpha and LH on proliferation of chicken granulosa cells and production of progesterone in culture. Onagbesan, O.M., Peddie, M.J. J. Reprod. Fertil. (1995) [Pubmed]
  16. Transformation of erythroid progenitors by viral and cellular tyrosine kinases. Beug, H., Schroeder, C., Wessely, O., Deiner, E., Meyer, S., Ischenko, I.D., Hayman, M.J. Cell Growth Differ. (1995) [Pubmed]
 
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