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Gene Review:

CYP1A2 - cytochrome P450, family 1, subfamily A,...

Gallus gallus

Gorman, N. et al., Bentivegna, C.S. et al., Mahajan, S.S. et al., Rifkind, A.B. et al.

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High impact information on CYP1A2

Further, whereas TCDD induces only CYP1A1 and not CYP1A2 in extrahepatic organs, TCDD induces both CYP1A4 and 1A5 in chick kidney [1].
A partial gene sequence for CYP1A5 indicated that the intron/exon organization of this gene was identical to that of the CYP1A1 and CYP1A2 mammalian genes and was present in a single copy in the genome [2].
The planar biphenyl, 3,3',4,4'-tetrachlorobiphenyl (TCB) stimulates uroporphyrinogen oxidation (UROX) in chick hepatic microsomes, but inhibits UROX activity in hepatic microsomes from mice and rats pre-induced by CYP1A2 [3].

Analytical, diagnostic and therapeutic context of CYP1A2

On Western blots non-immunopurified anti-TCDDAA and anti-TCDDAHH antisera recognized rat and guinea pig CYP1A1 and CYP1A2 [4].

References

Transcriptional activation of avian CYP1A4 and CYP1A5 by 2,3,7, 8-tetrachlorodibenzo-p-dioxin: differences in gene expression and regulation compared to mammalian CYP1A1 and CYP1A2. Mahajan, S.S., Rifkind, A.B. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
Developmental regulation of the 3-methylcholanthrene- and dioxin-inducible CYP1A5 gene in chick embryo liver in vivo. Bentivegna, C.S., Ihnat, M.A., Baptiste, N.S., Hamilton, J.W. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
CYP1A-catalyzed uroporphyrinogen oxidation in hepatic microsomes from non-mammalian vertebrates (chick and duck embryos, scup and alligator). Gorman, N., Walton, H.S., Sinclair, J.F., Sinclair, P.R. Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. (1998) [Pubmed]
Purification and biochemical characterization of two major cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in chick embryo liver. Rifkind, A.B., Kanetoshi, A., Orlinick, J., Capdevila, J.H., Lee, C. J. Biol. Chem. (1994) [Pubmed]

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