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Gene Review:

CBR1 - carbonyl reductase 1

Gallus gallus

Nishinaka, T. et al., Murphy, D.G. et al., Terada, T. et al.

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High impact information on CBR1

Menadione bisulfite, a watersoluble analog of Vitamin K3 which is a substrate for carbonyl reductase but not aldose reductase, was a competitive inhibitor of chicken aldose reductase with respect to substrate [1].
4. Cytosolic carbonyl reductase is a novel enzyme which can act on both testosterone and androsterone at low concentration [2].
CR1 exhibited 17 beta-hydroxysteroid dehydrogenase activity as well as carbonyl reductase activity in the presence of both NADP(H) and NAD(H) [3].
Three enzyme forms (CR1, CR2 and CR3) of carbonyl reductase were purified from chicken liver with using 4-benzoylpyridine as a substrate [3].

References

Inhibition studies on chicken muscle aldose reductase. Murphy, D.G., Davidson, W.S. Biochem. Pharmacol. (1985) [Pubmed]
Purification and characterization of carbonyl reductases from bovine liver cytosol and microsome. The cytosolic enzyme has a novel 3 alpha/17 beta-hydroxysteroid dehydrogenase activity. Terada, T., Niwase, N., Koyama, I., Imamura, M., Shinagawa, K., Toya, H., Mizoguchi, T. Int. J. Biochem. (1993) [Pubmed]
Characterization of multiple forms of carbonyl reductase from chicken liver. Nishinaka, T., Kinoshita, Y., Terada, N., Terada, T., Mizoguchi, T., Nishihara, T. Enzyme (1992) [Pubmed]

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AT5G51030	Arabidopsis thaliana
AT5G61830	Arabidopsis thaliana
CBR1	Bos taurus
LOC610164	Canis lupus familiaris
cbr1	Danio rerio
CBR1	Homo sapiens
CBR1	Macaca mulatta
Cbr1	Mus musculus
Os01g0929500	Oryza sativa Japonica Group
CBR1	Pan troglodytes
LOC100360507	Rattus norvegicus
Cbr1	Rattus norvegicus
LOC102556347	Rattus norvegicus
LOC101735101	Xenopus (Silurana) tropicalis
cbr3	Xenopus (Silurana) tropicalis
cbr1	Xenopus (Silurana) tropicalis

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