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GHRHR  -  growth hormone releasing hormone receptor

Gallus gallus

 
 
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High impact information on GHRHR

 

Biological context of GHRHR

  • We conclude that adrenal glucocorticoids may substantially impact pituitary GH responses to GHRH in the chicken through modulation of GHRH-R gene expression [2].
 

Anatomical context of GHRHR

  • As in those in mammals, chicken GHRHR is predominantly expressed in the pituitary and weakly expressed in several extra-pituitary tissues including brain, pancreas, testis, and kidney, among 12 tissues examined [3].
  • GHRH-R mRNA was readily detected by RT-PCR in the pituitary but not in the hypothalamus, total brain, lung, adrenal, ovary, or pineal gland [2].
 

Associations of GHRHR with chemical compounds

  • Whereas all treatments affected levels of GH mRNA, only CORT, GHRH, and SRIF significantly altered GHRH-R mRNA levels [2].
  • Bypassing the GHRH receptor through treatment with forskolin and 3-isobutyl-1-methylxanthine (IBMX) and phorbol 12-myristate-13-acetate failed to increase GH mRNA levels, suggesting that a lack of GHRH receptors alone cannot account for the lack of GHRH responses in the absence of CORT [4].

References

 
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