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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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MARK1  -  MAP/microtubule affinity-regulating kinase 1

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Psychiatry related information on MARK1

  • In spite of the blockage of long-term memory, which occurs by 3 hr, Mark and Watts [14] have demonstrated a short-term memory which is independent of protein synthesis and which decays over the 3 hr period [1].
 

High impact information on MARK1

  • We have previously reported the isolation of a hydrophobic, type-II collagen-binding glycoprotein of molecular weight 31,000 (31,000-mol-wt protein) from chick chondrocyte membranes (Mollenhauer, J., and K. von der Mark, EMBO Eur. Mol. Biol. Organ. J., 2:45-50) [2].
  • Cleavage of pM collagen under native conditions with pepsin gives rise to the collagen fragments M1 and M2, which had also been isolated from pepsin extracts of chick hyaline cartilage [K. von der Mark, M. van Menxel & H. Wiedemann (1982) Eur. J. Biochem. 124, 57-62] [3].
  • In an attempt to identify collagen-binding proteins on the chondrocyte surface, a protein of Mr 34KD, called Anchorin CII was isolated from chondrocyte membranes by affinity chromatography on type II collagen sepharose (Mollenhauer & von der Mark, 1983) [4].

References

  1. Effects of amphetamine on short-term, protein-independent, memory in day-old chickens. Gibbs, M.E. Pharmacol. Biochem. Behav. (1976) [Pubmed]
  2. Role of anchorin CII, a 31,000-mol-wt membrane protein, in the interaction of chondrocytes with type II collagen. Mollenhauer, J., Bee, J.A., Lizarbe, M.A., von der Mark, K. J. Cell Biol. (1984) [Pubmed]
  3. Isolation and characterization of a precursor form of M collagen from embryonic chicken cartilage. von der Mark, K., van Menxel, M., Wiedemann, H. Eur. J. Biochem. (1984) [Pubmed]
  4. Anchorin CII, a collagen-binding chondrocyte surface protein of the calpactin family. Pfäffle, M., Borchert, M., Deutzmann, R., von der Mark, K., Fernández, M.P., Selmin, O., Yamada, Y., Martin, G., Ruggiero, F., Garrone, R. Prog. Clin. Biol. Res. (1990) [Pubmed]
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