Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Cyp12a4 - CG6042 gene product from transcript CG6042-RA

Drosophila melanogaster

Synonyms: 12a4, CG6042, CYP12A4, CYPXIIA4, Dmel\CG6042, ...

Bogwitz, M.R. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Cyp12a4

Cyp12a4 confers lufenuron resistance in a natural population of Drosophila melanogaster [1].
Expression of Cyp12a4 in D. melanogaster third-instar larvae was detected in the midgut and Malpighian tubules of both lufenuron-resistant and wild-type strains [1].
Driving the expression of Cyp12a4 in the midgut and Malpighian tubules by using the GAL4/UAS gene expression system results in lufenuron resistance, but it does not result in resistance to three other insecticide classes [1].

Associations of Cyp12a4 with chemical compounds

The level of Cyp12a4 expression in the midgut is higher in the lufenuron-resistant strain than in wild-type strains [1].

References

Cyp12a4 confers lufenuron resistance in a natural population of Drosophila melanogaster. Bogwitz, M.R., Chung, H., Magoc, L., Rigby, S., Wong, W., O'Keefe, M., McKenzie, J.A., Batterham, P., Daborn, P.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.